Radiochemical pharmacokinetic profile of P10 peptide with antifungal properties

Radiochemical pharmacokinetic profile of P10 peptide with antifungal properties

Author Faintuch, Bluma L. Google Scholar
Oliveira, Erica A. Google Scholar
Munoz, Julian E. Google Scholar
Travassos, Luiz R. Autor UNIFESP Google Scholar
Taborda, Carlos Pelleschi Autor UNIFESP Google Scholar
Institution Inst Energy & Nucl Res
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Paracoccidioidomycosis (PCM) is a chronic granulomatous disease that is caused by the thermally dimorphic fungus Paracoccidioides brasiliensis. It is endemic in some countries of Latin America and can cause a high-burden fungal infection with significant morbidity and mortality. the peptide P10, which demonstrates immune protection against experimental PCM, was radiolabeled with a radioisotope and evaluated in vivo. the radiolabeling was conducted to trace the pharmacokinetics of the molecule in principal organs and tissues. This was achieved with high radiochemical purity. Biodistribution and scintigraphic imaging showed fast blood clearance that was mainly renal; however, hepatobiliar excretion was also, with marked uptake in cervical lymph nodes. This profile may be useful for the development of a prophylactic drug or vaccine for patients exposed to PCM.
Keywords P10 peptide
P. brasiliensis
radiolabeling
biodistribution evaluation
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2011/17267-4
Date 2014-07-01
Published in Medical Mycology. London: Informa Healthcare, v. 52, n. 5, p. 544-548, 2014.
ISSN 1369-3786 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 544-548
Origin http://dx.doi.org/10.1093/mmy/myu024
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000339914400012
URI http://repositorio.unifesp.br/handle/11600/37890

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