Treatment of Pediatric Takayasu Arteritis With Infliximab and Cyclophosphamide Experience From an American-Brazilian Cohort Study

Treatment of Pediatric Takayasu Arteritis With Infliximab and Cyclophosphamide Experience From an American-Brazilian Cohort Study

Author Stern, Sara Google Scholar
Clemente, Gleice Autor UNIFESP Google Scholar
Reiff, Andreas Google Scholar
Romao Ramos, Margarida Paula Autor UNIFESP Google Scholar
Marzan, Katherine Anne Google Scholar
Terreri, Maria Teresa Autor UNIFESP Google Scholar
Institution Univ Utah
Universidade Federal de São Paulo (UNIFESP)
Univ So Calif
Abstract Background: Pediatric Takayasu arteritis (pTA) is difficult to treat and can lead to significant morbidity and mortality.Objectives: the objective of this study was to describe clinical characteristics for pTA and determine the safety and efficacy of cyclophosphamide (CYC) and infliximab (IFX) in pTA.Methods: This was a retrospective analysis of 23 pTA patients seen at Children's Hospital Los Angeles and Universidade Federal de São Paulo-Brazil from 1990 to 2011. All patients fulfilled the 1990 American College of Rheumatology criteria for Takayasu arteritis. Disease activity was assessed using a modified National Institutes of Health score.Results: Twenty-three patients (14 female and 9 male patients), mean age of 15.7 +/- 6.0 years, were included. Cyclophosphamide was used before IFX treatment in 17 of 23 and IFX before CYC in 2 of 23 patients. the average time from disease onset to treatment initiation was 2.6 +/- 2.4 years for CYC and 4.1 +/- 2.4 years for IFX. Nine (60%) of 15 patients failed CYC, and of these 6 were changed to IFX with subsequent clinical stabilization in 5 (83%) of 6. Two patients initially treated with IFX were switched to CYC because of lack of appropriate response: 1 patient later worsened, and the other was lost to follow-up. Five opportunistic infections requiring hospitalization occurred in the CYC group, whereas none were observed in the IFX group. Patients in the IFX group were more likely to decrease or stop their corticosteroids when compared with the CYC patients.Conclusions: Cyclophosphamide is often used as initial treatment but has many adverse effects. in this retrospective case series, IFX was equivalent to CYC with fewer adverse effects, making IFX an alternative therapeutic option for pTA.
Keywords Takayasu arteritis
pediatric vasculitis
and infliximab
Language English
Date 2014-06-01
Published in Jcr-Journal of Clinical Rheumatology. Philadelphia: Lippincott Williams & Wilkins, v. 20, n. 4, p. 183-188, 2014.
ISSN 1076-1608 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 183-188
Access rights Closed access
Type Article
Web of Science ID WOS:000337159800002

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