Diffusion tensor imaging of the cervical spinal cord of patients with Neuromyelitis Optica

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dc.contributor.author Rivero, Rene L. M. [UNIFESP]
dc.contributor.author Oliveira, Enedina M. L. [UNIFESP]
dc.contributor.author Bichuetti, Denis B. [UNIFESP]
dc.contributor.author Gabbai, Alberto Alain [UNIFESP]
dc.contributor.author Nogueira, Roberto G. [UNIFESP]
dc.contributor.author Abdala, Nitamar [UNIFESP]
dc.date.accessioned 2016-01-24T14:37:23Z
dc.date.available 2016-01-24T14:37:23Z
dc.date.issued 2014-06-01
dc.identifier http://dx.doi.org/10.1016/j.mri.2014.01.023
dc.identifier.citation Magnetic Resonance Imaging. New York: Elsevier B.V., v. 32, n. 5, p. 457-463, 2014.
dc.identifier.issn 0730-725X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37835
dc.description.abstract Background: Previous studies have demonstrated a correlation between Expanded Disability Status Scale (EDSS) and Diffusion Tensor Imaging (DTI) metrics, but the conclusions were based on evaluations of the entire cervical spinal cord.Objectives: the purpose of this study was to quantify the FA and MD values in the spinal cord of NMO patients, separating the lesion sites from the preserved sites, which has not been previously preformed. in addition, we attempted to identify a correlation with EDSS.Methods: DTI was performed in 11 NMO patients and 11 healthy individuals using a 1.5-T MRI scanner. We measured the FA and MD at ROIs positioned along the cervical spinal cord. the mean values of FA and MD at lesion, preserved and spinal cord sites were compared with those of a control group. We tested the correlations between the mean FA and MD with EDSS.Results: FA in NMO patients was significantly reduced in lesion sites (0.44 vs. 0.55, p = 0.0046), preserved sites (0.46 vs. 0.55, p = 0.0015), and all sites (0.45 vs 0.55, p = 0.0013) while MD increased only in lesion sites (1.03 x 10(-3) mm(2)/s vs. 0.90 x 10(-3) mm(2)/s, p = 0.009). the FA demonstrated the best correlation with EDSS (r = -0.7603, p = 0.0086), particularly at lesion sites.Conclusions: the results reinforce the importance of the FA index and confirm the hypothesis that NMO is a diffuse disease. (C) 2014 Elsevier Inc. All rights reserved. en
dc.description.sponsorship TEVA Pharmaceutical (Brazilian branch)
dc.format.extent 457-463
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Magnetic Resonance Imaging
dc.rights Acesso restrito
dc.subject Neuromyelitis optica en
dc.subject Diffusion tensor imaging en
dc.subject Spinal cord en
dc.subject Disability evaluation en
dc.title Diffusion tensor imaging of the cervical spinal cord of patients with Neuromyelitis Optica en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Dept Diagnost Imagem, BR-04024002 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Dept Neurol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Dept Diagnost Imagem, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Dept Neurol, BR-04024002 São Paulo, Brazil
dc.identifier.doi 10.1016/j.mri.2014.01.023
dc.description.source Web of Science
dc.identifier.wos WOS:000335422800008



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