Association of nonalcoholic fatty Liver disease with cardiovascular risk factors in obese adolescents: the role of interdisciplinary therapy

Association of nonalcoholic fatty Liver disease with cardiovascular risk factors in obese adolescents: the role of interdisciplinary therapy

Author Sanches, Priscila L. Autor UNIFESP Google Scholar
Piano, Aline de Autor UNIFESP Google Scholar
Campos, Raquel M. S. Autor UNIFESP Google Scholar
Carnier, June Autor UNIFESP Google Scholar
Mello, Marco T. de Autor UNIFESP Google Scholar
Elias, Natalia Google Scholar
Fonseca, Francisco A. H. Autor UNIFESP Google Scholar
Masquio, Deborah C. L. Autor UNIFESP Google Scholar
Silva, Patricia L. da Google Scholar
Corgosinho, Flavia C. Autor UNIFESP Google Scholar
Tock, Lian Google Scholar
Oyama, Lila M. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Damaso, Ana R. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Assoc Fund Incent Res
Weight Sci
Universidade Federal de Goiás (UFG)
Abstract BACKGROUND: Obesity is associated with several cardiovascular risk factors, including nonalcoholic fatty liver disease (NAFLD). These risk factors can induce changes in the arteries such as an increase in the carotid intima-media thickness (cIMT), which contributes to the early development of atherosclerosis.OBJECTIVE: To determine whether NAFLD is associated with an atherogenic lipid profile, inflammatory markers, or cIMT in obese adolescents and to compare the effects of therapeutic lifestyle changes in NAFLD and non-NAFLD groups.METHODS: A total of 79 obese adolescents were divided into two groups: 33 NAFLD and 46 non-NAFLD. They were submitted to an interdisciplinary therapy involving diet exercise and psychological support during the course of 1 year. the cIMT and estimates of fat mass (liver, intra-abdominal, and subcutaneous) were determined ultrasonographically. Body composition, glucose, lipid profile, and adipokines were analyzed before and after the therapy.RESULTS: At baseline, only in the NAFLD group was the homeostasis model assessment of insulin resistance positively correlated with cIMT and triglyceride/high-density lipoprotein cholesterol ratio. Therapy was associated with an increase in adiponectin concentrations and reduced visceral fat, cIMT, leptin, and plasminogen activator inhibitor-1 concentrations, as well as the ratios of total cholesterol/high-density lipoprotein cholesterol and triglycerides/high-density lipoprotein cholesterol in both groups. Only in the non-NAFLD group did therapy result in a reduction in the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and increased high-density lipoprotein cholesterol concentration.CONCLUSIONS: in obese adolescents, NAFLD is associated with cardiovascular risk factors and inflammatory markers of atherosclerosis that were positively correlated with cIMT only in the NAFLD group. Nevertheless, the strength of the present study is that the interdisciplinary therapy effectively improved cIMT and other proinflammatory adipokines in both groups. (C) 2014 National Lipid Association. All rights reserved.
Keywords Cardiovascular risk factors
Interdisciplinary intervention
Non-alcoholic fatty liver disease
Language English
Sponsor CEPE-GEO Interdisciplinary Obesity Intervention Program: AFIP
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Universidade Federal de São Paulo
Grant number FAPESP: 2008/53069-0
FAPESP: 2011/50356-0
FAPESP: 2011/50414-0
FAPESP: 9814303-3
CAPES: 2011/2566
Date 2014-06-01
Published in Journal of Clinical Lipidology. New York: Elsevier B.V., v. 8, n. 3, p. 265-272, 2014.
ISSN 1933-2874 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 265-272
Access rights Closed access
Type Article
Web of Science ID WOS:000335284200005

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