Manic Symptoms in Youth: Dimensions, Latent Classes, and Associations With Parental Psychopathology

Manic Symptoms in Youth: Dimensions, Latent Classes, and Associations With Parental Psychopathology

Author Pan, Pedro Mario Autor UNIFESP Google Scholar
Salum, Giovanni Abrahao Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Moriyama, Tais Autor UNIFESP Google Scholar
Cogo-Moreira, Hugo Autor UNIFESP Google Scholar
Graeff-Martins, Ana Soledade Google Scholar
Rosario, Maria Conceicao Autor UNIFESP Google Scholar
Polanczyk, Guilherme Vanoni Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Rohde, Luis Augusto Google Scholar
Stringaris, Argyris Google Scholar
Goodman, Robert Google Scholar
Leibenluft, Ellen Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Rio Grande do Sul
Universidade de São Paulo (USP)
Kings Coll London
Abstract Objective: the purpose of the study was to define the latent structure of parent-reported manic symptoms and their association with functional impairment and familial risk in a community sample of Brazilian children. Method: We screened for manic symptoms in a community sample of 2,512 children 6 to 12 years of age. Parents of children with episodes of going abnormally high completed a detailed mania section (n = 479; 19.1%). Confirmatory factor analysis (CFA) tested a solution with Under-Control (UC) and Exuberant (EX) dimensions, investigating the severity (threshold) and factor loading of each symptom. We also used latent class analysis (LCA) to evaluate the latent categorical structure of manic symptoms. Associations of these latent constructs with psychiatric comorbidity, psychosocial impairment, and family history of psychopathology were tested. Results: the 2-dimensional model fit the data well. Only the UC dimension was associated with psychiatric morbidity, psychosocial impairment, and a family history of mania, depression, or suicide attempts. Both UC and EX items discriminated subjects with episodes of going abnormally high, but EX items lay at the mild end of the severity spectrum, whereas UC items lay at the severe end. the LCA yielded a small group of children with high levels of manic symptoms and a distinct profile of psychiatric comorbidity and impairment (high-symptom group). Conclusion: in a large, community-based sample, we found a 2-dimensional latent structure for parent-reported manic symptoms in youth, and demonstrated familial associations between the UC dimension and affective disorders. Both UC and EX items are clinically useful, but their contributions vary with symptom severity.
Keywords mania
family history
factor analysis
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2014-06-01
Published in Journal of the American Academy of Child and Adolescent Psychiatry. Amsterdam: Elsevier B.V., v. 53, n. 6, p. 625-634, 2014.
ISSN 0890-8567 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 625-634
Access rights Closed access
Type Article
Web of Science ID WOS:000336560400006

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