Structural Crystalline Characterization of Sakuranetin - An Antimicrobial Flavanone from Twigs of Baccharis retusa (Asteraceae)

Structural Crystalline Characterization of Sakuranetin - An Antimicrobial Flavanone from Twigs of Baccharis retusa (Asteraceae)

Author Grecco, Simone dos S. Autor UNIFESP Google Scholar
Dorigueto, Antonio C. Google Scholar
Landre, Iara M. Google Scholar
Soares, Marisi G. Google Scholar
Martho, Kevin Autor UNIFESP Google Scholar
Lima, Ricardo Autor UNIFESP Google Scholar
Pascon, Renata Castiglioni Autor UNIFESP Google Scholar
Vallim, Marcelo Afonso Autor UNIFESP Google Scholar
Capello, Tabata M. Autor UNIFESP Google Scholar
Romoff, Paulete Google Scholar
Sartorelli, Patricia Autor UNIFESP Google Scholar
Lago, Joao Henrique Ghilardi Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do ABC (UFABC)
Univ Fed Alfenas
Univ Presbiteriana Mackenzie
Abstract Bioactivity-guided fractionation of an antimicrobial active extract from twigs of Baccharis retusa C. DC. (Asteraceae) yielded the flavanone 5,4'-dihydroxy-7-methoxy-flavanone (sakuranetin) as responsible for the detected activity. the structure of the bioactive compound was established on the basis of spectroscopic data analysis, including NMR and MS. Additionally, the structure of a new crystal form of sakuranetin was confirmed by X-ray diffratometry. the minimum inhibitory concentrations (MIC) of isolated compound were determined against pathogenic yeast belonging to the genus Candida (six species), Cryptococcus (two species/four serotypes) and S. cerevisiae BY 4742 (S288c background) and ranged from 0.32 to 0.63 mu g/mu L. Our results showed that sakuranetin, which structure was fully characterized, could be used as a tool for the design of novel and more efficacious antifungal agents.
Keywords Baccharis retusa
sakuranetin
X-ray diffratometry
antimicrobial activity
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundacao de Amparo Pesquisa do Estado de Minas Gerais
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: FAPESP-2006/57626-5
FAPESP: 2011/51739-0
FAPESP: 2011/51298-4
Fundacao de Amparo Pesquisa do Estado de Minas Gerais: FAPEMIG-APQ-02600-12
Fundacao de Amparo Pesquisa do Estado de Minas Gerais: PPM-00524-12
Date 2014-06-01
Published in Molecules. Basel: Mdpi Ag, v. 19, n. 6, p. 7528-7542, 2014.
ISSN 1420-3049 (Sherpa/Romeo, impact factor)
Publisher Mdpi Ag
Extent 7528-7542
Origin http://dx.doi.org/10.3390/molecules19067528
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000338586700038
URI http://repositorio.unifesp.br/handle/11600/37812

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