NMDA and AMPA/Kainate Glutamatergic Receptors in the Prelimbic Medial Prefrontal Cortex Modulate the Elaborated Defensive Behavior and Innate Fear-Induced Antinociception Elicited by GABA(A) Receptor Blockade in the Medial Hypothalamus

NMDA and AMPA/Kainate Glutamatergic Receptors in the Prelimbic Medial Prefrontal Cortex Modulate the Elaborated Defensive Behavior and Innate Fear-Induced Antinociception Elicited by GABA(A) Receptor Blockade in the Medial Hypothalamus

Author Freitas, Renato Leonardo de Google Scholar
Salgado-Rohner, Carlos Jose Google Scholar
Biagioni, Audrey Francisco Google Scholar
Medeiros, Priscila Autor UNIFESP Google Scholar
Cecilio Hallak, Jaime Eduardo Google Scholar
Crippa, Jose Alexandre S. Google Scholar
Coimbra, Norberto Cysne Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Fed Rio Grande do Sul
Abstract The aim of the present study was to investigate the involvement of N-methyl-d-aspartate (NMDA) and amino-3-hydroxy-5-methyl-isoxazole-4-proprionate (AMPA)/kainate receptors of the prelimbic (PL) division of the medial prefrontal cortex (MPFC) on the panic attack-like reactions evoked by gamma-aminobutyric acid-A receptor blockade in the medial hypothalamus (MH). Rats were pretreated with NaCl 0.9%, LY235959 (NMDA receptor antagonist), and NBQX (AMPA/kainate receptor antagonist) in the PL at 3 different concentrations. Ten minutes later, the MH was treated with bicuculline, and the defensive responses were recorded for 10 min. the antagonism of NMDA receptors in the PL decreased the frequency and duration of all defensive behaviors evoked by the stimulation of the MH and reduced the innate fear-induced antinociception. However, the pretreatment of the PL cortex with NBQX was able to decrease only part of defensive responses and innate fear-induced antinociception. the present findings suggest that the NMDA-glutamatergic system of the PL is critically involved in panic-like responses and innate fear-induced antinociception and those AMPA/kainate receptors are also recruited during the elaboration of fear-induced antinociception and in panic attack-related response. the activation of the glutamatergic neurotransmission of PL division of the MPFC during the elaboration of oriented behavioral reactions elicited by the chemical stimulation of the MH recruits mainly NMDA receptors in comparison with AMPA/kainate receptors.
Keywords amino-3-hydroxy-5-methyl-isoxazole-4-proprionate
kainate receptors
gamma-aminobutyric acid-A receptors
dorsomedial hypothalamus
innate fear-induced antinociception
N-methyl-d-aspartate receptors
panic-like behavior
prelimbic medial prefrontal cortex
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
FAEPA
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Magister Scientiae (M.Sc.) fellowship
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number CNPq: 483763/2010-1
CNPq: 135930/2009-0
CNPq: 301905/2010-0
FAEPA: 345/2009
FAPESP: 01/03752-6
FAPESP: 2009/17258-5
FAPESP: 2008/08955-1
FAPESP: 2010/15140-4
FAPESP: 2010/14446-2
Magister Scientiae (M.Sc.) fellowship: 03/05256-1
Date 2014-06-01
Published in Cerebral Cortex. Cary: Oxford Univ Press Inc, v. 24, n. 6, p. 1518-1528, 2014.
ISSN 1047-3211 (Sherpa/Romeo, impact factor)
Publisher Oxford Univ Press Inc
Extent 1518-1528
Origin http://dx.doi.org/10.1093/cercor/bht001
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000336529700010
URI http://repositorio.unifesp.br/handle/11600/37792

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