Emerging sporotrichosis is driven by clonal and recombinant Sporothrix species

Emerging sporotrichosis is driven by clonal and recombinant Sporothrix species

Author Rodrigues, Anderson Messias Autor UNIFESP Google Scholar
Sybren de Hoog, G. Google Scholar
Zhang, Yu Google Scholar
Camargo, Zoilo Pires de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
KNAW Fungal Biodivers Ctr
Abstract Sporotrichosis, caused by agents of the fungal genus Sporothrix, occurs worldwide, but the infectious species are not evenly distributed. Sporothrix propagules usually gain entry into the warm-blooded host through minor trauma to the skin from contaminated plant debris or through scratches or bites from felines carrying the disease, generally in the form of outbreaks. Over the last decade, sporotrichosis has changed from a relatively obscure endemic infection to an epidemic zoonotic health problem. We evaluated the impact of the feline host on the epidemiology, spatial distribution, prevalence and genetic diversity of human sporotrichosis. Nuclear and mitochondrial markers revealed large structural genetic differences between S. brasiliensis and S. schenckii populations, suggesting that the interplay of host, pathogen and environment has a structuring effect on the diversity, frequency and distribution of Sporothrix species. Phylogenetic data support a recent habitat shift within S. brasiliensis from plant to cat that seems to have occurred in southeastern Brazil and is responsible for its emergence. A clonal structure was found in the early expansionary phase of the cathuman epidemic. However, the prevalent recombination structure in the plant-associated pathogen S. schenckii generates a diversity of genotypes that did not show any significant increase in frequency as etiological agents of human infection over time. These results suggest that closely related pathogens can follow different strategies in epidemics. Thus, species-specific types of transmission may require distinct public health strategies for disease control.
Keywords emerging infectious diseases
epidemiology
fungi
outbreak
Sporothrix
sporotrichosis
zoonosis
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenacao de Aperfeic, oamento de Pessoal de Nivel Superior
National Council for Scientific and Technological Development
Coordenacao de Aperfeic, oamento de Pessoal de Nivel Superio
Grant number FAPESP: 2011/07350-1
FAPESP: 2009/54024-2
Coordenacao de Aperfeic, oamento de Pessoal de Nivel Superior: BEX 2325/11-0
National Council for Scientific and Technological Development: 472600/2011-7
Date 2014-05-07
Published in Emerging Microbes & Infections. London: Nature Publishing Group, v. 3, 10 p., 2014.
ISSN 2222-1751 (Sherpa/Romeo, impact factor)
Publisher Nature Publishing Group
Extent 10
Origin http://dx.doi.org/10.1038/emi.2014.33
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000339238100002
URI http://repositorio.unifesp.br/handle/11600/37764

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