Ascaris lumbricoides infection in urban schoolchildren: Specific IgE and IL-10 production

Ascaris lumbricoides infection in urban schoolchildren: Specific IgE and IL-10 production

Author Souza, V. Google Scholar
Medeiros, D. Google Scholar
Sales, I. Google Scholar
Costa, V. Google Scholar
Silva, A. Google Scholar
Rizzo, J. Google Scholar
Sole, D. Autor UNIFESP Google Scholar
Sarinho, E. Google Scholar
Institution Universidade Federal de Pernambuco (UFPE)
Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Helminth infections and allergies are diseases with intense Th2 lymphocytes participation and characterised by a high IgE and Interleukin-(IL) IL-4, IL-5 production and eosinophilia. However, helminths also induce IL-10 production, which may alter the outcome of allergic diseases in infected patients.Objective: This experimental study analyses the relationship between IL-10 production by cell culture from geohelminth infected and non-infected children and specific IgE to Ascaris lumbricoides (Asc) or Blomia tropicalis (BT).Methods: IL-10 content in supernatant from peripheral blood mononuclear cell culture from nine helminth infected and eleven non-infected patients was determined by ELISA after in vitro stimulation with Asc or BT extracts.Results: A positive association was observed between total IgE levels and anti-Ascaris and anti-Btomia tropicalis specific IgE, independent of infection status. for both helminth-infected and non-infected groups, there was no difference in IL-10 production in response to Asc extract, even though anti-Ascaris IgE levels were higher in the latter group. in response to BT stimulus, a lower production of IL-10 by the geohelminth-infected group was observed, but with no relationship between IL-10 production and specific IgE to BT.Conclusion: the results suggest that anti-Ascaris IgE in non-infected patients may be associated to a resistance to parasites. Levels of specific IgE to parasite antigens or B. tropicalis allergen were not impaired by IL-10 production in children from an urban area in which geohelminthiasis is endemic. (C) 2012 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.
Keywords Ascaris lumbricoides
Blomia tropicalis
Urban area
Immunoglobulin E
Language English
Sponsor Ministerio da Saude - MS
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number CNPq: 402666/2005-4
Date 2014-05-01
Published in Allergologia Et Immunopathologia. Barcelona: Elsevier Doyma Sl, v. 42, n. 3, p. 206-211, 2014.
ISSN 0301-0546 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 206-211
Access rights Closed access
Type Article
Web of Science ID WOS:000337266200006

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