Strategies to manage hepatitis C virus (HCV) disease burden

Strategies to manage hepatitis C virus (HCV) disease burden

Author Wedemeyer, H. Google Scholar
Duberg, A. S. Google Scholar
Buti, M. Google Scholar
Rosenberg, W. M. Google Scholar
Frankova, S. Google Scholar
Esmat, G. Google Scholar
Ormeci, N. Google Scholar
Van Vlierberghe, H. Google Scholar
Gschwantler, M. Google Scholar
Akarca, U. Google Scholar
Aleman, S. Google Scholar
Balik, I. Google Scholar
Berg, T. Google Scholar
Bihl, F. Google Scholar
Bilodeau, M. Google Scholar
Blasco, A. J. Google Scholar
Brandao Mello, C. E. Google Scholar
Bruggmann, P. Google Scholar
Calinas, F. Google Scholar
Calleja, J. L. Google Scholar
Cheinquer, H. Google Scholar
Christensen, P. B. Google Scholar
Clausen, M. Google Scholar
Coelho, H. S. M. Google Scholar
Cornberg, M. Google Scholar
Cramp, M. E. Google Scholar
Dore, G. J. Google Scholar
Doss, W. Google Scholar
El-Sayed, M. H. Google Scholar
Ergor, G. Google Scholar
Estes, C. Google Scholar
Falconer, K. Google Scholar
Felix, J. Google Scholar
Ferraz, Maria Lucia Gomes Autor UNIFESP Google Scholar
Ferreira, Paulo Roberto Autor UNIFESP Google Scholar
Garcia-Samaniego, J. Google Scholar
Gerstoft, J. Google Scholar
Giria, J. A. Google Scholar
Goncales, F. L. Google Scholar
Guimaraes Pessoa, M. Google Scholar
Hezode, C. Google Scholar
Hindman, S. J. Google Scholar
Hofer, H. Google Scholar
Husa, P. Google Scholar
Idilman, R. Google Scholar
Kaberg, M. Google Scholar
Kaita, K. D. E. Google Scholar
Kautz, A. Google Scholar
Kaymakoglu, S. Google Scholar
Krajden, M. Google Scholar
Krarup, H. Google Scholar
Laleman, W. Google Scholar
Lavanchy, D. Google Scholar
Lazaro, P. Google Scholar
Marinho, R. T. Google Scholar
Marotta, P. Google Scholar
Mauss, S. Google Scholar
Mendes Correa, M. C. Google Scholar
Moreno, C. Google Scholar
Muellhaupt, B. Google Scholar
Myers, R. P. Google Scholar
Nemecek, V. Google Scholar
Ovrehus, A. L. H. Google Scholar
Parkes, J. Google Scholar
Peltekian, K. M. Google Scholar
Ramji, A. Google Scholar
Razavi, H. Google Scholar
Reis, N. Google Scholar
Roberts, S. K. Google Scholar
Roudot-Thoraval, F. Google Scholar
Ryder, S. D. Google Scholar
Sarmento-Castro, R. Google Scholar
Sarrazin, C. Google Scholar
Semela, D. Google Scholar
Sherman, M. Google Scholar
Shiha, G. E. Google Scholar
Sperl, J. Google Scholar
Starkel, P. Google Scholar
Stauber, R. E. Google Scholar
Thompson, A. J. Google Scholar
Urbanek, P. Google Scholar
Van Damme, P. Google Scholar
van Thiel, I. Google Scholar
Vandijck, D. Google Scholar
Vogel, W. Google Scholar
Waked, I. Google Scholar
Weis, N. Google Scholar
Wiegand, J. Google Scholar
Yosry, A. Google Scholar
Zekry, A. Google Scholar
Negro, F. Google Scholar
Sievert, W. Google Scholar
Gower, E. Google Scholar
Institution Hannover Med Sch
German Liver Fdn
Orebro Univ Hosp
Univ Orebro
Hosp Valle de Hebron
UCL
Inst Clin & Expt Med
Cairo Univ
Ankara Univ
Ghent Univ Hosp
Wilhelminenspital Stadt Wien
Ege Univ
Karolinska Inst
Karolinska Univ Hosp
Univ Leipzig
Osped Cantonale
Univ Montreal
Adv Tech Hlth Serv Res TAISS
Fed Univ State Rio de Janeiro
Arud Ctr Addict Med
Hosp Santo Antonio Capuchos
Hosp Puerta Hierro
Univ Fed Rio Grande do Sul
Odense Univ Hosp
Region Hosp Hovedstaden
Universidade Federal do Rio de Janeiro (UFRJ)
Univ Plymouth
Univ New S Wales
Ain Shams Univ
Dokuz Eylul Univ
Ctr Dis Anal CDA
Exigo Consultores
Universidade Federal de São Paulo (UNIFESP)
Hosp Carlos III
Univ Copenhagen
Direccao Geral Saude
Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Hop Henri Mondor
Med Univ Vienna
Masaryk Univ
Univ Manitoba
Hlth Sci Ctr
European Liver Patients Assoc
Istanbul Univ
Univ British Columbia
Aalborg Univ Hosp
Katholieke Univ Leuven
Univ Western Ontario
Univ Dusseldorf
Univ Libre Brussels
Univ Zurich Hosp
Univ Calgary
Natl Inst Publ Hlth
Univ Southhampton
Dalhousie Univ & Hepatol Serv
Assembleia Republ
Alfred Hosp
Monash Univ
Nottingham Univ Hosp NHS Trust
Biomed Res Unit
Ctr Hosp Porto
JW Goethe Univ Hosp
Cantonal Hosp St Gallen
Univ Toronto
Egyptian Liver Res Inst & Hosp ELRIAH
Catholic Univ Louvain
Med Univ Graz
St Vincents Hosp
Univ Melbourne
Charles Univ Prague
Cent Mil Hosp
Univ Antwerp
Deutsch Leberhilfe eV
Univ Ghent
Hasselt Univ
Med Univ Innsbruck
Natl Liver Inst
Copenhagen Univ Hosp
Univ Hosp
Monash Hlth
Abstract The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. the largest reduction in HCV-related morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10%, this analysis suggests it is possible to achieve elimination of HCV (defined as a >90% decline in total infections by 2030). However, for most countries presented, this will require a 3-5 fold increase in diagnosis and/or treatment. Thus, building the public health and clinical provider capacity for improved diagnosis and treatment will be critical.
Keywords diagnosis
epidemiology
HCV
mortality
treatment
scenarios
prevalence
incidence
hepatitis C
disease burden
Language English
Sponsor Gilead Sciences
Date 2014-05-01
Published in Journal of Viral Hepatitis. Hoboken: Wiley-Blackwell, v. 21, p. 60-89, 2014.
ISSN 1352-0504 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 60-89
Origin http://dx.doi.org/10.1111/jvh.12249
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000333893200004
URI http://repositorio.unifesp.br/handle/11600/37689

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