The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm

The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm

Author Razavi, H. Google Scholar
Waked, I. Google Scholar
Sarrazin, C. Google Scholar
Myers, R. P. Google Scholar
Idilman, R. Google Scholar
Calinas, F. Google Scholar
Vogel, W. Google Scholar
Mendes Correa, M. C. Google Scholar
Hezode, C. Google Scholar
Lazaro, P. Google Scholar
Akarca, U. Google Scholar
Aleman, S. Google Scholar
Balik, I. Google Scholar
Berg, T. Google Scholar
Bihl, F. Google Scholar
Bilodeau, M. Google Scholar
Blasco, A. J. Google Scholar
Brandao Mello, C. E. Google Scholar
Bruggmann, P. Google Scholar
Buti, M. Google Scholar
Calleja, J. L. Google Scholar
Cheinquer, H. Google Scholar
Christensen, P. B. Google Scholar
Clausen, M. Google Scholar
Coelho, H. S. M. Google Scholar
Cramp, M. E. Google Scholar
Dore, G. J. Google Scholar
Doss, W. Google Scholar
Duberg, A. S. Google Scholar
El-Sayed, M. H. Google Scholar
Ergor, G. Google Scholar
Esmat, G. Google Scholar
Falconer, K. Google Scholar
Felix, J. Google Scholar
Ferraz, Maria Lucia Gomes Autor UNIFESP Google Scholar
Ferreira, Paulo Roberto Autor UNIFESP Google Scholar
Frankova, S. Google Scholar
Garcia-Samaniego, J. Google Scholar
Gerstoft, J. Google Scholar
Giria, J. A. Google Scholar
Goncales, F. L. Google Scholar
Gower, E. Google Scholar
Gschwantler, M. Google Scholar
Guimaraes Pessoa, M. Google Scholar
Hindman, S. J. Google Scholar
Hofer, H. Google Scholar
Husa, P. Google Scholar
Kaberg, M. Google Scholar
Kaita, K. D. E. Google Scholar
Kautz, A. Google Scholar
Kaymakoglu, S. Google Scholar
Krajden, M. Google Scholar
Krarup, H. Google Scholar
Laleman, W. Google Scholar
Lavanchy, D. Google Scholar
Marinho, R. T. Google Scholar
Marotta, P. Google Scholar
Mauss, S. Google Scholar
Moreno, C. Google Scholar
Murphy, K. Google Scholar
Negro, F. Google Scholar
Nemecek, V. Google Scholar
Ormeci, N. Google Scholar
Ovrehus, A. L. H. Google Scholar
Parkes, J. Google Scholar
Pasini, K. Google Scholar
Peltekian, K. M. Google Scholar
Ramji, A. Google Scholar
Reis, N. Google Scholar
Roberts, S. K. Google Scholar
Rosenberg, W. M. Google Scholar
Roudot-Thoraval, F. Google Scholar
Ryder, S. D. Google Scholar
Sarmento-Castro, R. Google Scholar
Semela, D. Google Scholar
Sherman, M. Google Scholar
Shiha, G. E. Google Scholar
Sievert, W. Google Scholar
Sperl, J. Google Scholar
Starkel, P. Google Scholar
Stauber, R. E. Google Scholar
Thompson, A. J. Google Scholar
Urbanek, P. Google Scholar
Van Damme, P. Google Scholar
van Thiel, I. Google Scholar
Van Vlierberghe, H. Google Scholar
Vandijck, D. Google Scholar
Wedemeyer, H. Google Scholar
Weis, N. Google Scholar
Wiegand, J. Google Scholar
Yosry, A. Google Scholar
Zekry, A. Google Scholar
Cornberg, M. Google Scholar
Muellhaupt, B. Google Scholar
Estes, C. Google Scholar
Institution Ctr Dis Anal
Natl Liver Inst
JW Goethe Univ Hosp
Univ Calgary
Ankara Univ
Hosp Santo Antonio Capuchos
Med Univ Innsbruck
Universidade de São Paulo (USP)
Hop Henri Mondor
Adv Tech Hlth Serv Res TAISS
Ege Univ
Karolinska Inst
Karolinska Univ Hosp
Univ Leipzig
Osped Cantonale
Univ Montreal
Fed Univ State Rio de Janeiro
Arud Ctr Addict Med
Hosp Valle de Hebron
Hosp Puerta Hierro
Univ Fed Rio Grande do Sul
Odense Univ Hosp
Reg Hosp Hovedstaden
Universidade Federal do Rio de Janeiro (UFRJ)
Univ Plymouth
Univ New S Wales
Cairo Univ
Orebro Univ Hosp
Univ Orebro
Ain Shams Univ
Dokuz Eylul Univ
Exigo Consultores
Universidade Federal de São Paulo (UNIFESP)
Inst Clin & Expt Med
Hosp Carlos III
Univ Copenhagen
Direccao Geral Saude
Universidade Estadual de Campinas (UNICAMP)
Wilhelminenspital Stadt Wien
Med Univ Vienna
Masaryk Univ
Univ Manitoba
Hlth Sci Ctr
European Liver Patients Assoc
Istanbul Univ
Univ British Columbia
Aalborg Univ Hosp
Katholieke Univ Leuven
Hosp Santa Maria
Univ Western Ontario
Univ Dusseldorf
Univ Libre Brussels
Univ Hosp
Natl Inst Publ Hlth
Univ Southhampton
Dalhousie Univ & Hepatol Serv
Assembleia Republ
Alfred Hosp
Monash Univ
UCL
Nottingham Univ Hosp NHS Trust
Biomed Res Unit
Ctr Hosp Porto
Cantonal Hosp St Gallen
Univ Toronto
Egyptian Liver Res Inst & Hosp
Monash Hlth
Catholic Univ Louvain
Med Univ Graz
St Vincents Hosp
Univ Melbourne
Charles Univ Prague
Cent Mil Hosp
Univ Antwerp
Deutsch Leberhilfe eV
Ghent Univ Hosp
Univ Ghent
Hannover Med Sch
Copenhagen Univ Hosp
Univ Zurich Hosp
Abstract The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. in addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing.
Keywords HCV
diagnosis
treatment
hepatitis C
prevalence
epidemiology
disease burden
mortality
incidence
Language English
Sponsor Gilead Sciences
Date 2014-05-01
Published in Journal of Viral Hepatitis. Hoboken: Wiley-Blackwell, v. 21, p. 34-59, 2014.
ISSN 1352-0504 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 34-59
Origin http://dx.doi.org/10.1111/jvh.12248
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000333893200003
URI http://repositorio.unifesp.br/handle/11600/37688

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account