Carbamazepine-exposure during gestation and lactation affects pubertal onset and spermatic parameters in male pubertal offspring

Carbamazepine-exposure during gestation and lactation affects pubertal onset and spermatic parameters in male pubertal offspring

Author Andretta, Rhayza Roberta Autor UNIFESP Google Scholar
Okada, Fatima Kazue Autor UNIFESP Google Scholar
Paccola, Camila Cicconi Autor UNIFESP Google Scholar
Stumpp, Taiza Autor UNIFESP Google Scholar
Oliva, Samara Urban de Autor UNIFESP Google Scholar
Miraglia, Sandra M. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Carbamazepine (CBZ) is an anti-epileptic drug that acts on Leydig cells, affecting steroidogenesis and causes fetal malformation. the aim of this study was to investigate the effects of CBZ on male sexual maturation and other male parameters. Rat dams were treated with CBZ during pregnancy and breastfeeding. the anogenital distance (AGD) and the anogenital index (AGI) were obtained. Testicular descent and preputial separation were also evaluated. the offspring was euthanized at PND 41 and 63. the accessory glands were weighed and the testes were collected for histopathological, morphometric and sterological analyses. the numerical density of Leydig cells and hormone dosage were obtained. CBZ caused an increase of AGI and a delay of testicular descent and of preputial separation. CBZ also caused a decrease of testosterone level and of sperm count and an increase of abnormal sperm. These results indicate that CBZ delays puberty onset and affects steroidogenesis and sperm quality. (C) 2013 Elsevier Inc. All rights reserved.
Keywords Carbamazepine
Testosterone
Puberty
Sperm parameters
Rat
Pregnancy
Breastfeeding
Leydig cell
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2012/05905-9
Date 2014-04-01
Published in Reproductive Toxicology. Oxford: Pergamon-Elsevier B.V., v. 44, p. 52-62, 2014.
ISSN 0890-6238 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 52-62
Origin http://dx.doi.org/10.1016/j.reprotox.2013.09.009
Access rights Closed access
Type Article
Web of Science ID WOS:000335368500009
URI http://repositorio.unifesp.br/handle/11600/37625

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account