Radiation-grafting of thermo- and pH-responsive poly (N-vinylcaprolactam-co-acrylic acid) onto silicone rubber and polypropylene films for biomedical purposes

Radiation-grafting of thermo- and pH-responsive poly (N-vinylcaprolactam-co-acrylic acid) onto silicone rubber and polypropylene films for biomedical purposes

Author Ferraz, Caroline C. Google Scholar
Varca, Gustavo H. C. Google Scholar
Ruiz, Juan-Carlos Google Scholar
Lopes, Patricia S. Autor UNIFESP Google Scholar
Mathor, Monica B. Google Scholar
Lugao, Ademar B. Google Scholar
Bucio, Emilio Google Scholar
Institution Inst Pesquisas Energet & Nucl IPEN CNEN SP
Univ Nacl Autonoma Mexico
Universidade Federal de São Paulo (UNIFESP)
Abstract This work focuses on the effects of gamma-ray irradiation conditions on the stimuli-responsiveness of polypropylene (PP) films and silicone (SR) rubber substrates grafted with N-vinylcaprolactam (NVCL) and acrylic acid (AAc). PP films and SR rubber were modified by simultaneous polymerization and grafting of NVCL and AAc, using pre-irradiation oxidative method at a dose rate of 1223 kGy h(-1) and doses ranging from 5 to 70 kGy. NVCL and AAc solutions (1/1, v/v) at 50% monomer concentration (v/v) in toluene were added to the sample substrates, degassed, sealed and heated at 60 and 70 degrees C for 12 h. After grafting, the samples were soaked in ethanol and distilled water for 24 h successively, followed by drying under vacuum. Samples were characterized by FTIR-ATR, DSC and swelling measurements. Critical points (pH critical or LCST) of grafts were obtained in a pH-environment (pH ranges from 2.2 to 9) and in a thermo-environment (temperature ranges from 22 to 50 C). Cytotoxicity evaluation was performed using fibroblast BALB/c 3T3 cells. the relationship between NVCL-co-AAc grafting and radiation dose was different for each substrate, PP and SR. At 50% NVCL/AAc concentration in toluene, grafting values were higher for SR than for PP. Despite the fact that PP-g-(NVCL-co-AAc) membrane presented a cytotoxic profile at the highest experimental concentration assayed, cytotoxicity evaluation revealed noncytotoxic profiles for the membranes synthesized highlighting their applications for biomedical purposes. (C) 2013 Elsevier B.V. All rights reserved.
Keywords Radiation-grafting
Stimuli responsive film
Acrylic acid
N-vinylcaprolactam
Cytotoxicity
Fibroblast BALB/c 3T3
Language English
Sponsor DGAPA-UNAM
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Ibero-American Programme for Science, and Technology and Development of CYTED
Grant number DGAPA-UNAM: IN202311
CNPq: 174378
Date 2014-04-01
Published in Radiation Physics and Chemistry. Oxford: Pergamon-Elsevier B.V., v. 97, p. 298-303, 2014.
ISSN 0969-806X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 298-303
Origin http://dx.doi.org/10.1016/j.radphyschem.2013.12.027
Access rights Closed access
Type Article
Web of Science ID WOS:000332052800044
URI http://repositorio.unifesp.br/handle/11600/37624

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