Gender and hemispheric differences in temporal lobe epilepsy: A VBM study

Gender and hemispheric differences in temporal lobe epilepsy: A VBM study

Author Santana, Maria Teresa Castilho Garcia de Autor UNIFESP Google Scholar
Jackowski, Andrea Parolin Autor UNIFESP Google Scholar
Britto, Fernanda dos Santos Autor UNIFESP Google Scholar
Sandim, Gabriel Barbosa Autor UNIFESP Google Scholar
Caboclo, Luís Otávio Sales Ferreira Autor UNIFESP Google Scholar
Centeno, Ricardo Silva Autor UNIFESP Google Scholar
Carrete Junior, Henrique Autor UNIFESP Google Scholar
Yacubian, Elza Márcia Targas Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: Gender differences are recognized in the functional and anatomical organization of the human brain. Differences between genders are probably expressed early in life, when differential rates of cerebral maturation occur. Sexual dimorphism has been described in temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS). Several voxel-based morphometry (VBM) studies have shown that TLE-MTS extends beyond mesial temporal structures, and that there are differences in the extent of anatomical damage between hemispheres, although none have approached gender differences. Our aim was to investigate gender differences and anatomical abnormalities in TLE-MTS.Methods: VBM5 was employed to analyze gender and hemispheric differences in 120 patients with TLE-MTS and 50 controls.Results: VBM abnormalities were more widespread in left-TLE; while in women changes were mostly seen in temporal areas, frontal regions were more affected in men.Conclusions: Our study confirmed that gender and laterality are important factors determining the nature and severity of brain damage in TLE-MTS. Differential rates of maturation between gender and hemispheres may explain the distinct areas of anatomical damage in men and women. (C) 2013 British Epilepsy Association. Published by Elsevier B.V. All rights reserved.
Keywords Gender
Mesial temporal sclerosis
Temporal lobe epilepsy
Voxel-based morphometry
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2014-04-01
Published in Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 23, n. 4, p. 274-279, 2014.
ISSN 1059-1311 (Sherpa/Romeo, impact factor)
Publisher W B Saunders Co Ltd
Extent 274-279
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000334980700005

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