Social isolation disrupts hippocampal neurogenesis in young non-human primates

Social isolation disrupts hippocampal neurogenesis in young non-human primates

Author Cinini, Simone Maria Autor UNIFESP Google Scholar
Barnabe, Gabriela Filoso Autor UNIFESP Google Scholar
Galvao-Coelho, Nicole Google Scholar
Medeiros, Magda A. de Google Scholar
Perez-Mendes, Patricia Autor UNIFESP Google Scholar
Sousa, Maria B. C. Google Scholar
Covolan, Luciene Autor UNIFESP Google Scholar
Mello, Luiz Eugenio Araujo de Moraes Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Rio Grande do Norte
Univ Fed Rural Rio de Janeiro
Abstract Social relationships are crucial for the development and maintenance of normal behavior in non-human primates. Animals that are raised in isolation develop abnormal patterns of behavior that persist even when they are later reunited with their parents. in rodents, social isolation is a stressful event and is associated with a decrease in hippocampal neurogenesis but considerably less is known about the effects of social isolation in non-human primates during the transition from adolescence to adulthood. To investigate how social isolation affects young marmosets, these were isolated from other members of the colony for 1 or 3 weeks and evaluated for alterations in their behavior and hippocampal cell proliferation. We found that anxiety-related behaviors like scent-marking and locomotor activity increased after social isolation when compared to baseline levels. in agreement, grooming an indicative of attenuation of tension was reduced among isolated marmosets. These results were consistent with increased cortisol levels after 1 and 3 weeks of isolation. After social isolation (1 or 3 weeks), reduced proliferation of neural cells in the subgranular zone of dentate granule cell layer was identified and a smaller proportion of BrdU-positive cells underwent neuronal fate (doublecortin labeling). Our data is consistent with the notion that social deprivation during the transition from adolescence to adulthood leads to stress and produces anxiety-like behaviors that in turn might affect neurogenesis and contribute to the deleterious consequences of prolonged stressful conditions.
Keywords social isolation
young marmosets
hippocampal neurogenesis
isolation stress
Language English
Date 2014-03-27
Published in Frontiers in Neuroscience. Lausanne: Frontiers Research Foundation, v. 8, 9 p., 2014.
ISSN 1662-453X (Sherpa/Romeo, impact factor)
Publisher Frontiers Research Foundation
Extent 9
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000346437600001

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