HDL cholesterol levels and weight are the main determinants of subclinical atherosclerosis in the young with type 1 diabetes and suitable glycaemic control

HDL cholesterol levels and weight are the main determinants of subclinical atherosclerosis in the young with type 1 diabetes and suitable glycaemic control

Author Pinto, Camila S. Autor UNIFESP Google Scholar
Lana, Janaina M. Autor UNIFESP Google Scholar
Gabbay, Monica Andrade Lima Autor UNIFESP Google Scholar
Sa, Joao R. de Autor UNIFESP Google Scholar
Dib, Sergio A. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The aim of this study was to evaluate subclinical atherosclerosis and related factors in young type 1 diabetes (T1D) patients and healthy peers. Carotid intima-media thickness (cIMT) and anthropometric/laboratorial data were obtained for 83 T1D patients (mean age 19.5 +/- 4.0 years, disease duration 9.8 +/- 4.8 years) and for 36 matched healthy subjects. Considering all the participants as one group, male sex (p = 0.008), weight (p = 0.016) and T1D (p < 0.001) were positively associated with a higher cIMT. High-density lipoprotein (HDL) (p = 0.036) was negatively associated with cIMT in T1D. in the male T1D patients, HDL <= 47.5 mg/dL had a sensitivity of 87.5% and specificity of 57% (p = 0.035) in detecting those belonging to a higher cIMT tercile. in conclusion, weight and T1D were associated with increased cIMT. HDL levels <= 47.5 mg/dL were related to a higher cIMT in male T1D patients.
Keywords high-density lipoprotein (HDL) cholesterol
weight
carotid intima-media thickness
Type 1 diabetes
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2014-03-01
Published in Diabetes & Vascular Disease Research. London: Sage Publications Ltd, v. 11, n. 2, p. 125-128, 2014.
ISSN 1479-1641 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Ltd
Extent 125-128
Origin http://dx.doi.org/10.1177/1479164114523146
Access rights Closed access
Type Article
Web of Science ID WOS:000331433300009
URI http://repositorio.unifesp.br/handle/11600/37527

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