Effects of cannabinoid and vanilloid drugs on positive and negative-like symptoms on an animal model of schizophrenia: the SHR strain

Effects of cannabinoid and vanilloid drugs on positive and negative-like symptoms on an animal model of schizophrenia: the SHR strain

Author Almeida, Valeria Autor UNIFESP Google Scholar
Peres, Fernanda F. Autor UNIFESP Google Scholar
Levin, Raquel Autor UNIFESP Google Scholar
Suiama, Mayra A. Autor UNIFESP Google Scholar
Calzavara, Mariana B. Autor UNIFESP Google Scholar
Zuardi, Antonio W. Google Scholar
Hallak, Jaime E. Google Scholar
Crippa, Jose A. Google Scholar
Abilio, Vanessa C. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Natl Inst Translat Med INCT TM
Abstract Studies have suggested that the endocannabinoid system is implicated in the pathophysiology of schizophrenia. We have recently reported that Spontaneously Hypertensive Rats (SHRs) present a deficit in social interaction that is ameliorated by atypical antipsychotics. in addition, SHRs display hyperlocomotion - reverted by atypical and typical antipsychotics. These results suggest that this strain could be useful to study negative symptoms (modeled by a decrease in social interaction) and positive symptoms (modeled by hyperlocomotion) of schizophrenia and the effects of potential drugs with an antipsychotic profile. the aim of this study was to investigate the effects of WIN55-212,2 (CB1/CB2 agonist), ACEA (CB1 agonist), rimonabant (CB1 inverse agonist), AM404 (anandamide uptake/metabolism inhibitor), capsaicin (agonist TRPV1) and capsazepine (antagonist TRPV1) on the social interaction and locomotion of control animals (Wistar rats) and SHRs. the treatment with rimonabant was not able to alter either the social interaction or the locomotion presented by Wistar rats (WR) and SHR at any dose tested. the treatment with WIN55-212,2 decreased locomotion (1 mg/kg) and social interaction (0.1 and 0.3 mg/kg) of WR, while the dose of 1 mg/kg increased social interaction of SHR. the treatment with ACEA increased (0.3 mg/kg) and decreased (1 mg/kg) locomotion of both strain. the administration of AM404 increased social interaction and decreased locomotion of SHR (5 mg/kg), and decreased social interaction and increased locomotion in WR (1 mg/kg). the treatment with capsaicin (2.5 mg/kg) increased social interaction of both strain and decreased locomotion of SHR (2.5 mg/kg) and WR (0.5 mg/kg and 2.5 mg/kg). in addition, capsazepine (5 mg/kg) decreased locomotion of both strains and increased (5 mg/kg) and decreased (10 mg/kg) social interaction of WR. Our results indicate that the schizophrenia-like behaviors displayed by SHR are differently altered by cannabinoid and vanilloid drugs when compared to control animals and suggest the endocannabinoid and the vanilloid systems as a potential target for the treatment of schizophrenia. (C) 2014 Elsevier B. V. All rights reserved.
Keywords Cannabinoids
Vanilloid drugs
Schizophrenia
Social interaction
Hyperlocomotion
SHR
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: FAPESP - 2010/07994-3
Date 2014-03-01
Published in Schizophrenia Research. Amsterdam: Elsevier B.V., v. 153, n. 1-3, p. 150-159, 2014.
ISSN 0920-9964 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 150-159
Origin http://dx.doi.org/10.1016/j.schres.2014.01.039
Access rights Closed access
Type Article
Web of Science ID WOS:000333052800023
URI http://repositorio.unifesp.br/handle/11600/37499

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