Acute total sleep deprivation potentiates amphetamine-induced locomotor-stimulant effects and behavioral sensitization in mice

Acute total sleep deprivation potentiates amphetamine-induced locomotor-stimulant effects and behavioral sensitization in mice

Author Saito, Luis P. Autor UNIFESP Google Scholar
Fukushiro, Daniela F. Autor UNIFESP Google Scholar
Hollais, Andre W. Autor UNIFESP Google Scholar
Mari-Kawamoto, Elisa Autor UNIFESP Google Scholar
Costa, Jacqueline M. Autor UNIFESP Google Scholar
Berro, Lais F. Autor UNIFESP Google Scholar
Aramini, Tatiana C. F. Autor UNIFESP Google Scholar
Wuo-Silva, Raphael Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Florida State Univ
Abstract It has been demonstrated that a prolonged period (48 h) of paradoxical sleep deprivation (PSD) potentiates amphetamine (AMP)-induced behavioral sensitization, an animal model of addiction-related neuroadaptations. in the present study, we examined the effects of an acute short-term deprivation of total sleep (TSD) (6 h) on AMP-induced behavioral sensitization in mice and compared them to the effects of short-term PSD (6 h). Three-month-old male C57BL/6J mice underwent TSD (experiment 1 gentle handling method) or PSD (experiment 2 multiple platforms method) for 6 h. Immediately after the sleep deprivation period, mice were tested in the open field for 10 min under the effects of saline or 2.0 mg/kg AMP. Seven days later, to assess behavioral sensitization, all of the mice received a challenge injection of 2.0 mg/kg AMP and were tested in the open field for 10 mm. Total, peripheral, and central locomotion, and grooming duration were measured. TSD, but not PSD, potentiated the hyperlocomotion induced by an acute injection of AMP and this effect was due to an increased locomotion in the central squares of the apparatus. Similarly, TSD facilitated the development of AMP-induced sensitization, but only in the central locomotion parameter. the data indicate that an acute period of TSD may exacerbate the behavioral effects of AMP in mice. Because sleep architecture is composed of paradoxical and slow wave sleep, and 6-h PSD had no effects on AMP-induced hyperlocomotion or sensitization, our data suggest that the deprivation of slow wave sleep plays a critical role in the mechanisms that underlie the potentiating effects of TSD on both the acute and sensitized addiction-related responses to AMP. (C) 2013 Elsevier Inc. All rights reserved.
Keywords Amphetamine
Behavioral sensitization
Hyperlocomotion
Mice
Paradoxical sleep deprivation
Total sleep deprivation
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundo de Apoio ao Docente e Aluno (FADA)
Associacao Fundo de Incentivo a Pesquisa (AFIP)
Date 2014-02-01
Published in Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 117, p. 7-16, 2014.
ISSN 0091-3057 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 7-16
Origin http://dx.doi.org/10.1016/j.pbb.2013.11.032
Access rights Closed access
Type Article
Web of Science ID WOS:000331501500002
URI http://repositorio.unifesp.br/handle/11600/37386

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