Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells

Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells

Author Machado-Neto, Joao Agostinho Google Scholar
Campos, Paula de Melo Google Scholar
Favaro, Patricia Autor UNIFESP Google Scholar
Lazarini, Mariana Google Scholar
Lorand-Metze, Irene Google Scholar
Costa, Fernando Ferreira Google Scholar
Olalla Saad, Sara Teresinha Google Scholar
Traina, Fabiola Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Stathmin 1 is an important cytoplasmic microtubule-destabilizing protein that plays critical roles in proliferation and accurate chromosome segregation through regulation of microtubule dynamics. High levels of Stathmin 1 expression have been reported in leukemia and solid tumors. However, Stathmin 1 has not been studied in myelodysplastic syndrome cells. We, herein, report that significantly higher Stathmin 1 levels were observed in proliferating hematopoietic cells, in high-risk MDS and acute leukemia cells. in addition, Stathmin 1 silencing in U937 and Namalwa leukemia cells reduced cell proliferation and clonogenicity. Our data suggest that Stathmin 1 expression may be related to the highly proliferative phenotype of hematopoietic cells and add new insights into the participation of Stathmin 1 in hematological malignancies. (C) 2013 Elsevier B.V. All rights reserved.
Keywords Stathmin 1
OP18
Myelodysplastic syndromes
Acute myeloid leukemia
Acute lymphoid leukemia
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2014-02-01
Published in Leukemia Research. Oxford: Pergamon-Elsevier B.V., v. 38, n. 2, p. 251-257, 2014.
ISSN 0145-2126 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 251-257
Origin http://dx.doi.org/10.1016/j.leukres.2013.11.013
Access rights Closed access
Type Article
Web of Science ID WOS:000329971200020
URI http://repositorio.unifesp.br/handle/11600/37378

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