Whole-body magnetic resonance imaging in the assessment of muscular involvement in juvenile dermatomyositis/polymyositis patients

Whole-body magnetic resonance imaging in the assessment of muscular involvement in juvenile dermatomyositis/polymyositis patients

Author Castro, T. C. M. Autor UNIFESP Google Scholar
Lederman, H. Autor UNIFESP Google Scholar
Terreri, M. T. Autor UNIFESP Google Scholar
Caldana, W. I. Autor UNIFESP Google Scholar
Zanoteli, E. Google Scholar
Hilario, M. O. E. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Objectives: Our aim was to demonstrate the benefit of whole-body magnetic resonance imaging (WBMRI) as a diagnostic modality in the detection of muscle activity in juvenile dermatomyositis (JDM)/polymyositis (JPM) patients and to correlate these findings with clinical evaluation, laboratory examinations, nailfold capillaroscopy (NFC), and muscle biopsy.Method: Thirty-four patients aged 5.5 to 18.9 years with a diagnosis of JDM/JPM were prospectively evaluated using clinical examination, muscle enzyme determination, the Childhood Myositis Assessment Scale (CMAS), Disease Activity Score (DAS), Manual Muscle Testing (MMT), NFC, and WBMRI. An open muscle biopsy was performed if muscle disease activity was detected on WBMRI.Results: Disease activity was detected in WBMRI in four (11.7%) patients and confirmed by muscle biopsy. All four patients had elevation of at least one muscle enzyme and NFC showed scleroderma patterns in these patients.Conclusions: WBMRI allows us to evaluate the extent and symmetry of muscle disease and inflammatory activity. NFC is an important additional examination to assess disease activity.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 10/51424-7
Date 2014-01-01
Published in Scandinavian Journal of Rheumatology. London: Informa Healthcare, v. 43, n. 4, p. 329-333, 2014.
ISSN 0300-9742 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 329-333
Origin http://dx.doi.org/10.3109/03009742.2013.868509
Access rights Closed access
Type Article
Web of Science ID WOS:000340461800012
URI http://repositorio.unifesp.br/handle/11600/37296

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