Neuromyelitis Optica With Onset in Childhood and Adolescence

Neuromyelitis Optica With Onset in Childhood and Adolescence

Author Fragoso, Yara Dadalti Google Scholar
Ferreira, Maria L. B. Google Scholar
Oliveira, Enedina M. L. Autor UNIFESP Google Scholar
Domingues, Renan B. Google Scholar
Ribeiro, Taysa A. G. J. Google Scholar
Brooks, Joseph B. B. Google Scholar
Claudino, Rinaldo Google Scholar
Netto, Jussara M. K. Google Scholar
Gomes, Sidney Google Scholar
Adoni, Tarso Google Scholar
Carneiro, Denise S. D. Google Scholar
Fonseca, Daiana R. P. Google Scholar
Fragomeni, Manuela O. Autor UNIFESP Google Scholar
Oliveira, Francisco T. M. Google Scholar
Oliveira, Celso L. S. Google Scholar
Saldanha, Patricia C. O. Google Scholar
Souza, Jorge M. B. Google Scholar
Institution Univ Metropolitana Santos
Hosp Restauracao
Universidade Federal de São Paulo (UNIFESP)
Santa Casa Vitoria
Universidade Federal de Goiás (UFG)
Universidade Federal de Santa Catarina (UFSC)
Universidade Federal do Rio de Janeiro (UFRJ)
Hosp Beneficencia Portuguesa
Hosp Paulistano
Hosp Sirio Libanes
Abstract BACKGROUND: Neuromyelitis optica with onset before the age of 18 years is a relatively rare, yet potentially devastating condition. the objective of the present study was to contribute to the study of early-onset neuromyelitis optica with a case series. PATIENTS: Data were collected from medical records of Brazilian neurologists caring for patients with neuromyelitis optica occurring in childhood and adolescence. RESULTS: Twenty-nine patients with neuromyelitis optica occurring before the age of 18 years and fulfilling the diagnostic criteria were identified. the average age at disease onset was 13 years and the patients had had an average disease duration of 6 years. the expanded disability scale score at the latest consultation was, on average, 4.7, and one patient had died from the disease. the 29 patients had had an average 4.5 relapses during the disease, accounting for 0.75 relapses per year, irrespective of the medication used. All patients were using one or more of the following medications: azathioprine, prednisone, immunoglobulin, and glatiramer acetate. CONCLUSIONS: Neuromyelitis optica with onset in childhood and adolescence is a poorly understood condition that is often disabling and difficult to manage.
Keywords neuromyelitis optica
Devic
children
adolescents
demyelinating diseases
multiple sclerosis
Language English
Date 2014-01-01
Published in Pediatric Neurology. New York: Elsevier B.V., v. 50, n. 1, p. 66-68, 2014.
ISSN 0887-8994 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 66-68
Origin http://dx.doi.org/10.1016/j.pediatrneurol.2013.07.003
Access rights Closed access
Type Article
Web of Science ID WOS:000329601200011
URI http://repositorio.unifesp.br/handle/11600/37247

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