Is Lack of Sleep Capable of Inducing DNA Damage in Aged Skin?

Is Lack of Sleep Capable of Inducing DNA Damage in Aged Skin?

Author Kahan, Vanessa Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Egydio, Flavia Autor UNIFESP Google Scholar
Barros, L. A. Autor UNIFESP Google Scholar
Tomimori, Jane Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Skin naturally changes with age, becoming more fragile. Various stimuli can alter skin integrity. the aim of this study was to evaluate whether sleep deprivation affects the integrity of DNA in skin and exacerbates the effects of aging. Fifteen-month old female Hairless mice underwent 72 h of paradoxical sleep deprivation or 15 days of chronic sleep restriction. Punch biopsies of the skin were taken to evaluate DNA damage by single cell gel (comet) assay. Neither paradoxical sleep deprivation nor sleep restriction increased genetic damage, measured by tail movement and tail intensity values. Taken together, the findings are consistent with the notion that aging overrides the effect of sleep loss on the genetic damage in elderly mice. (C) 2014 S. Karger AG, Basel
Keywords Skin
Elderly
Sleep deprivation
Mice
Single cell gel (comet) assay
DNA damage
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 09/04240-0
FAPESP: 07/01228-4
FAPESP: 11/14462-0
Date 2014-01-01
Published in Skin Pharmacology and Physiology. Basel: Karger, v. 27, n. 3, p. 127-131, 2014.
ISSN 1660-5527 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 127-131
Origin http://dx.doi.org/10.1159/000354915
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000330633900003
URI http://repositorio.unifesp.br/handle/11600/37206

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