Association between ABCB1 Immunohistochemical Expression and Overall Survival in Gastric Cancer Patients

Association between ABCB1 Immunohistochemical Expression and Overall Survival in Gastric Cancer Patients

Author Oliveira, Juliana de Autor UNIFESP Google Scholar
Felipe, Aledson Vitor Autor UNIFESP Google Scholar
Artigiani Neto, Ricardo Autor UNIFESP Google Scholar
Oshima, Celina Tizuko Autor UNIFESP Google Scholar
Silva, Marcelo de Souza Autor UNIFESP Google Scholar
Forones, Nora Manoukian Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Gastric cancer (GC) is one of the most common malignancies worldwide. the ABCB1 protein, a member of the ATP-binding cassette (ABC) transporter family, encoded by the ABCB1 gene, considerably influences the distribution of drugs across cell membranes as well as multidrug resistance (MDR) of antineoplastic drugs. in contrast to the extensive knowledge on the pharmacological action of ABCB1 protein, the correlation between the clinical-pathological data and ABCB1 protein expression in patients with GC remains unclear. the aim was to investigate association between ABCB1 expression and overall survival in GC patients. Human tumor fragments from 57 GC patients were examined by immunohistochemistry assay. We observed lower survival rate of patients with GC who were positive for ABCB1 expression (p=0.030). Based on these observations, we conclude that GC patients with positive ABCB1 protein immunohistochemical expression in their tumors suffer shorter overall survival.
Keywords ABCB1
immunohistochemistry
gastric cancer
survival
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 10.19715-1
Date 2014-01-01
Published in Asian Pacific Journal of Cancer Prevention. Gyeonggi-do: Asian Pacific Organization Cancer Prevention, v. 15, n. 16, p. 6935-6938, 2014.
ISSN 1513-7368 (Sherpa/Romeo, impact factor)
Publisher Asian Pacific Organization Cancer Prevention
Extent 6935-6938
Origin http://dx.doi.org/10.7314/APJCP.2014.15.16.6935
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000343832900078
URI http://repositorio.unifesp.br/handle/11600/37204

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