Analysis of cardiac autonomic modulation of children with attention deficit hyperactivity disorder

Analysis of cardiac autonomic modulation of children with attention deficit hyperactivity disorder

Author Carvalho, Tatiana Dias de Autor UNIFESP Google Scholar
Wajnsztejn, Rubens Google Scholar
Abreu, Luiz Carlos de Google Scholar
Vanderlei, Luiz Carlos Marques Google Scholar
Godoy, Moacir Fernandes Google Scholar
Adami, Fernando Google Scholar
Valenti, Vitor Engrácia Autor UNIFESP Google Scholar
Monteiro, Carlos B. M. Google Scholar
Leone, Claudio Google Scholar
Martins, Karen Cristina da Cruz Google Scholar
Ferreira, Celso Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
FMABC
Univ Estadual Paulista
Universidade de São Paulo (USP)
Abstract Background: Attention deficit hyperactivity disorder (ADHD) is characterized by decreased attention span, impulsiveness, and hyperactivity. Autonomic nervous system imbalance was previously described in this population. We aim to compare the autonomic function of children with ADHD and controls by analyzing heart rate variability (HRV).Methods: Children rested in supine position with spontaneous breathing for 20 minutes. Heart rate was recorded beat by beat. HRV analysis was performed in the time and frequency domains and Poincare plot.Results: Twenty-eight children with ADHD (22 boys, aged 9.964 years) and 28 controls (15 boys, age 9.857 years) participated in this study. It was determined that the mean and standard deviation of indexes which indicate parasympathetic activity is higher in children with ADHD than in children without the disorder: high frequency in normalized units, 46.182 (14.159) versus 40.632 (12.247); root mean square of successive differences, 41.821 (17.834) versus 38.150 (18.357); differences between adjacent normal-to-normal intervals greater than 50 milliseconds, 199.75 (144.00) versus 127.46 (102.21) (P<0.05); percentage of differences between adjacent normal-to-normal intervals greater than 50 milliseconds, 23.957 (17.316) versus 16.211 (13.215); standard deviation of instantaneous beat-to-beat interval, 29.586 (12.622) versus 26.989 (12.983).Conclusion: Comparison of the autonomic function by analyzing HRV suggests an increase in the activity of the parasympathetic autonomic nervous systems in children with ADHD in relation to the control group.
Keywords attention deficit hyperactivity disorder
autonomic nervous system
children
heart rate variability
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2013/17628-2
Date 2014-01-01
Published in Neuropsychiatric Disease and Treatment. Albany: Dove Medical Press Ltd, v. 10, p. 613-618, 2014.
ISSN 1176-6328 (Sherpa/Romeo, impact factor)
Publisher Dove Medical Press Ltd
Extent 613-618
Origin http://dx.doi.org/10.2147/NDT.S49071
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000334318500001
URI http://repositorio.unifesp.br/handle/11600/37180

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