Jussara (Euterpe edulis Mart.) Supplementation during Pregnancy and Lactation Modulates the Gene and Protein Expression of Inflammation Biomarkers Induced by trans-Fatty Acids in the Colon of Offspring

Jussara (Euterpe edulis Mart.) Supplementation during Pregnancy and Lactation Modulates the Gene and Protein Expression of Inflammation Biomarkers Induced by trans-Fatty Acids in the Colon of Offspring

Author Morais, Carina Almeida Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Oliveira, Juliana Lopez de Autor UNIFESP Google Scholar
Garcia, Marcia Carvalho Autor UNIFESP Google Scholar
Rosso, Veridiana Vera de Autor UNIFESP Google Scholar
Mendes Amigo, Lais Sousa Autor UNIFESP Google Scholar
Oller do Nascimento, Claudia Maria Autor UNIFESP Google Scholar
Pisani, Luciana Pellegrini Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Maternal intake of trans-fatty acids (TFAs) in the perinatal period triggers a proinflammatory state in offspring. Anthocyanins contained in fruit are promising modulators of inflammation. This study investigated the effect of Jussara supplementation in the maternal diet on the proinflammatory state of the colon in offspring exposed to perinatal TFAs. On the first day of pregnancy rats were divided into four groups: control diet (C), control diet with 0.5% Jussara supplementation (CJ), diet enriched with hydrogenated vegetable fat, rich in TFAs (T), or T diet supplemented with 0.5% Jussara (TJ) during pregnancy and lactation. We showed that Jussara supplementation inmaternal diet (CJ and TJ groups) reduced carcass lipid/protein ratios, serumlipids, glucose, IL-6, TNF-alpha, gene expression of IL-6R, TNF-alpha R (P < 0.05), TLR-4 (P < 0.01), and increase Lactobacillus spp. (P < 0.05) in the colon of offspring compared to the T group. the IL-10 (P = 0.035) and IL-10/TNF-alpha ratio (P < 0.01) was higher in the CJ group than in the T group. the 0.5% Jussara supplementation reverses the adverse effects of perinatal TFAs, improving lipid profiles, glucose levels, body composition, and gut microbiota and reducing low-grade inflammation in the colon of 21-day-old offspring, and could contribute to reducing chronic disease development.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2014-01-01
Published in Mediators of Inflammation. New York: Hindawi Publishing Corporation, 11 p., 2014.
ISSN 0962-9351 (Sherpa/Romeo, impact factor)
Publisher Hindawi Publishing Corporation
Extent 11
Origin http://dx.doi.org/10.1155/2014/987927
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000344301100001
URI http://repositorio.unifesp.br/handle/11600/37164

Show full item record




File

Name: WOS000344301100001.pdf
Size: 1.663Mb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account