Theoretical Basis, Laboratory Evidence, and Clinical Research of Chemical Surgery of the Cornea: Cross-Linking

Theoretical Basis, Laboratory Evidence, and Clinical Research of Chemical Surgery of the Cornea: Cross-Linking

Author Paz, Amanda C. da Autor UNIFESP Google Scholar
Bersanetti, Patricia A. Autor UNIFESP Google Scholar
Salomao, Marcella Q. Google Scholar
Ambrosio, Renato Autor UNIFESP Google Scholar
Schor, Paulo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Inst Olhos Renato Ambrosio
Abstract Corneal cross-linking (CXL) is increasingly performed in ophthalmology with high success rates for progressive keratoconus and other types of ectasia. Despite being an established procedure, some molecular and clinical aspects still require additional studies. This review presents a critical analysis of some established topics and others that are still controversial. in addition, this review examines new technologies and techniques (transepithelial and ultrafast CXL), uses of corneal CXL including natural products and biomolecules as CXL promoters, and evidence for in vitro and in vivo indirect effectiveness.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 2012/07343-8
FAPESP: 2013/20857-3
Date 2014-01-01
Published in Journal of Ophthalmology. New York: Hindawi Publishing Corporation, 9 p., 2014.
ISSN 2090-004X (Sherpa/Romeo, impact factor)
Publisher Hindawi Publishing Corporation
Extent 9
Origin http://dx.doi.org/10.1155/2014/890823
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000344168700001
URI http://repositorio.unifesp.br/handle/11600/37160

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