International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies

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dc.contributor.author Agmon-Levin, Nancy
dc.contributor.author Damoiseaux, Jan
dc.contributor.author Kallenberg, Cees
dc.contributor.author Sack, Ulrich
dc.contributor.author Witte, Torsten
dc.contributor.author Herold, Manfred
dc.contributor.author Bossuyt, Xavier
dc.contributor.author Musset, Lucille
dc.contributor.author Cervera, Ricard
dc.contributor.author Plaza-Lopez, Aresio
dc.contributor.author Dias, Carlos
dc.contributor.author Sousa, Maria Jose
dc.contributor.author Radice, Antonella
dc.contributor.author Eriksson, Catharina
dc.contributor.author Hultgren, Olof
dc.contributor.author Viander, Markku
dc.contributor.author Khamashta, Munther
dc.contributor.author Regenass, Stephan
dc.contributor.author Coelho Andrade, Luis Eduardo [UNIFESP]
dc.contributor.author Wiik, Allan
dc.contributor.author Tincani, Angela
dc.contributor.author Ronnelid, Johan
dc.contributor.author Bloch, Donald B.
dc.contributor.author Fritzler, Marvin J.
dc.contributor.author Chan, Edward K. L.
dc.contributor.author Garcia-De la Torre, I.
dc.contributor.author Konstantinov, Konstantin N.
dc.contributor.author Lahita, Robert
dc.contributor.author Wilson, Merlin
dc.contributor.author Vainio, Olli
dc.contributor.author Fabien, Nicole
dc.contributor.author Sinico, Renato Alberto
dc.contributor.author Meroni, Pierluigi
dc.contributor.author Shoenfeld, Yehuda
dc.date.accessioned 2016-01-24T14:34:55Z
dc.date.available 2016-01-24T14:34:55Z
dc.date.issued 2014-01-01
dc.identifier http://dx.doi.org/10.1136/annrheumdis-2013-203863
dc.identifier.citation Annals of the Rheumatic Diseases. London: Bmj Publishing Group, v. 73, n. 1, p. 17-23, 2014.
dc.identifier.issn 0003-4967
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37125
dc.description.abstract Anti-nuclear antibodies (ANA) are fundamental for the diagnosis of autoimmune diseases, and have been determined by indirect immunofluorescence assay (IIFA) for decades. As the demand for ANA testing increased, alternative techniques were developed challenging the classic IIFA. These alternative platforms differ in their antigen profiles, sensitivity and specificity, raising uncertainties regarding standardisation and interpretation of incongruent results. Therefore, an international group of experts has created recommendations for ANA testing by different methods. Two groups of experts participated in this initiative. the European autoimmunity standardization initiative representing 15 European countries and the International Union of Immunologic Societies/World Health Organization/Arthritis Foundation/Centers for Disease Control and Prevention autoantibody standardising committee. A three-step process followed by a Delphi exercise with closed voting was applied. Twenty-five recommendations for determining ANA (1-13), anti-double stranded DNA antibodies (14-18), specific antibodies (19-23) and validation of methods (24-25) were created. Significant differences between experts were observed regarding recommendations 24-25 (p<0.03). Here, we formulated recommendations for the assessment and interpretation of ANA and associated antibodies. Notably, the roles of IIFA as a reference method, and the importance of defining nuclear and cytoplasmic staining, were emphasised, while the need to incorporate alternative automated methods was acknowledged. Various approaches to overcome discrepancies between methods were suggested of which an improved bench-to-bedside communication is of the utmost importance. These recommendations are based on current knowledge and can enable harmonisation of local algorithms for testing and evaluation of ANA and related autoantibodies. Last but not least, new more appropriate terminologies have been suggested. en
dc.format.extent 17-23
dc.language.iso eng
dc.publisher Bmj Publishing Group
dc.relation.ispartof Annals of the Rheumatic Diseases
dc.rights Acesso aberto
dc.subject Autoantibodies en
dc.subject Autoimmunity en
dc.subject Systemic Lupus Erythematosus en
dc.subject SjOgren's Syndrome en
dc.title International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies en
dc.type Resenha
dc.contributor.institution Chaim Sheba Med Ctr
dc.contributor.institution Tel Aviv Univ
dc.contributor.institution Maastricht Univ
dc.contributor.institution Univ Groningen
dc.contributor.institution Univ Leipzig
dc.contributor.institution Sch Med
dc.contributor.institution Med Univ Innsbruck
dc.contributor.institution Univ Hosp Leuven
dc.contributor.institution Katholieke Univ Leuven
dc.contributor.institution GH Pitie Salpetriere
dc.contributor.institution Hosp Clin Barcelona
dc.contributor.institution Hosp Univ Pueta Hierro Majadahonda
dc.contributor.institution S Joao Hosp
dc.contributor.institution Fernando Fonseca Hosp
dc.contributor.institution Azienda Osped Osped San Carlo Borromeo
dc.contributor.institution Umea Univ
dc.contributor.institution Univ Hosp Orebro
dc.contributor.institution Univ Orebro
dc.contributor.institution Univ Turku
dc.contributor.institution Kings Coll London
dc.contributor.institution DIA Univ Spital
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Statens Serum Inst
dc.contributor.institution Spedali Civil Brescia
dc.contributor.institution Univ Brescia
dc.contributor.institution Uppsala Univ
dc.contributor.institution Massachusetts Gen Hosp
dc.contributor.institution Harvard Univ
dc.contributor.institution Univ Calgary
dc.contributor.institution Univ Florida
dc.contributor.institution Hosp Gen Occidente Seguro Social
dc.contributor.institution Univ Guadalajara
dc.contributor.institution Newark Beth Israel Med Ctr UMDNJ
dc.contributor.institution Univ Oulu
dc.contributor.institution NordLab Oulu
dc.contributor.institution CH Lyon Sud
dc.contributor.institution Univ Milan
dc.description.affiliation Chaim Sheba Med Ctr, Zabludowicz Ctr Autoimmune Dis, Tel Aviv, Israel
dc.description.affiliation Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
dc.description.affiliation Maastricht Univ, Med Ctr, Cent Diagnost Lab, Maastricht, Netherlands
dc.description.affiliation Univ Groningen, Univ Med Ctr Groningen, Dept Rheumatol & Clin Immunol, Groningen, Netherlands
dc.description.affiliation Univ Leipzig, Inst Clin Immunol & Transfus Med, D-04109 Leipzig, Germany
dc.description.affiliation Sch Med, Dept Clin Immunol & Rheumatol, Hannover, Germany
dc.description.affiliation Med Univ Innsbruck, Rheumatol Unit, Dept Internal Med 1, A-6020 Innsbruck, Austria
dc.description.affiliation Univ Hosp Leuven, Louvain, Belgium
dc.description.affiliation Katholieke Univ Leuven, Dept Microbiol & Immunol, Louvain, Belgium
dc.description.affiliation GH Pitie Salpetriere, Dept Immunol, Paris, France
dc.description.affiliation Hosp Clin Barcelona, Dept Autoimmune Dis, Catalonia, Spain
dc.description.affiliation Hosp Univ Pueta Hierro Majadahonda, Serv Inmunol, Madrid, Spain
dc.description.affiliation S Joao Hosp, Dept Med, Autoimmune Dis Unit, Oporto, Portugal
dc.description.affiliation Fernando Fonseca Hosp, Autoimmun & PreNatal Diagnost Lab Unit, Oporto, Portugal
dc.description.affiliation Azienda Osped Osped San Carlo Borromeo, Inst Microbiol, Milan, Italy
dc.description.affiliation Umea Univ, Dept Clin Microbiol, Umea, Sweden
dc.description.affiliation Univ Hosp Orebro, Dept Lab Med, Orebro, Sweden
dc.description.affiliation Univ Orebro, SE-70182 Orebro, Sweden
dc.description.affiliation Univ Turku, Dept Med Microbiol & Immunol, Turku, Finland
dc.description.affiliation Kings Coll London, Div Womens Hlth, Lupus Res Lab, London WC2R 2LS, England
dc.description.affiliation DIA Univ Spital, Klin Immunol, Zurich, Switzerland
dc.description.affiliation Universidade Federal de São Paulo, Div Rheumatol, São Paulo, Brazil
dc.description.affiliation Statens Serum Inst, Dept Clin Chem & Immunol, DK-2300 Copenhagen S, Denmark
dc.description.affiliation Spedali Civil Brescia, Rheumatol & Clin Immunol Unit, Dept Clin & Expt Sci, I-25125 Brescia, Italy
dc.description.affiliation Univ Brescia, Brescia, Italy
dc.description.affiliation Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden
dc.description.affiliation Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol, Harvard, MA USA
dc.description.affiliation Harvard Univ, Sch Med, Harvard, MA USA
dc.description.affiliation Univ Calgary, Fac Med, Calgary, AB, Canada
dc.description.affiliation Univ Florida, Dept Oral Biol, Gainesville, FL 32610 USA
dc.description.affiliation Hosp Gen Occidente Seguro Social, Dept Immunol & Rheumatol, Guadalajara, Jalisco, Mexico
dc.description.affiliation Univ Guadalajara, Guadalajara 44430, Jalisco, Mexico
dc.description.affiliation Newark Beth Israel Med Ctr UMDNJ, Newark, NJ USA
dc.description.affiliation Newark Beth Israel Med Ctr UMDNJ, VP, Newark, NJ USA
dc.description.affiliation Univ Oulu, Inst Diagnost, Dept Med Microbiol & Immunol, Oulu, Finland
dc.description.affiliation NordLab Oulu, Oulu, Finland
dc.description.affiliation CH Lyon Sud, Dept Immunol, Pierre Benite, France
dc.description.affiliation Azienda Osped Osped San Carlo Borromeo, Clin Immunol Unit, Milan, Italy
dc.description.affiliation Azienda Osped Osped San Carlo Borromeo, Renal Unit, Milan, Italy
dc.description.affiliation Univ Milan, Div Rheumatol, Ist G Pini, Ist Auxol Italiano, Milan, Italy
dc.description.affiliation Tel Aviv Univ, Sackler Fac Med, Laura Schwarz Kip Chair Res Autoimmune Dis, IL-69978 Tel Aviv, Israel
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Rheumatol, São Paulo, Brazil
dc.identifier.doi 10.1136/annrheumdis-2013-203863
dc.description.source Web of Science
dc.identifier.wos WOS:000327835100009



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