Laser Doppler imaging for assessment of microcirculation in juvenile systemic sclerosis

Laser Doppler imaging for assessment of microcirculation in juvenile systemic sclerosis

Author Petry Piotto, Daniela Gerent Autor UNIFESP Google Scholar
Uchoa Correa, Marcelo Jose Autor UNIFESP Google Scholar
Miotto e Silva, Vanessa Bugni Autor UNIFESP Google Scholar
Kayser, Cristiane Autor UNIFESP Google Scholar
Terreri, Maria Teresa R. A. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objectives. the objectives of this study were to evaluate the dynamic behaviour of digital skin microvascular blood flow before and after cold stimulation using laser Doppler imaging (LDI) in children and adolescents with RP secondary to juvenile systemic sclerosis (JSS), primary RP (PRP) and healthy controls and to compare functional abnormalities measured by LDI with structural microvascular abnormalities evaluated by nailfold capillaroscopy (NFC).Methods. Five JSS patients, five children and adolescents with PRP and five healthy controls matched for gender and age were included. All subjects had NFC performed. Finger blood flow (FBF) was measured using the LDI system (Moor Instruments) at baseline and after cold stimulus (CS).Results. There were a decreased number of capillaries, a greater number of enlarged capillaries and a higher deletion score in JSS patients compared with controls and patients with PRP. the mean baseline FBF was significantly lower in JSS patients compared with controls. There was no difference between the mean baseline FBF in JSS patients compared with patients with PRP. There was a significant decrease in FBF 1 min after CS in all groups followed by blood flow recovery at 20 min after CS in comparison with basal FBF values in controls, but not in JSS and PRP patients.Conclusion. in JSS patients, LDI showed a lower FBF before and after CS compared with healthy controls and may be an objective and sensitive method for the measurement of digital skin blood flow in RP children.
Keywords juvenile systemic sclerosis
Raynaud's phenomenon
microcirculation
laser Doppler imaging
nailfold capillaroscopy
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 06/59073-3
Date 2014-01-01
Published in Rheumatology. Oxford: Oxford Univ Press, v. 53, n. 1, p. 72-75, 2014.
ISSN 1462-0324 (Sherpa/Romeo, impact factor)
Publisher Oxford Univ Press
Extent 72-75
Origin http://dx.doi.org/10.1093/rheumatology/ket288
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000329041900010
URI http://repositorio.unifesp.br/handle/11600/37120

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