Executive functioning in obstructive sleep apnea syndrome patients without comorbidities: Focus on the fractionation of executive functions

Executive functioning in obstructive sleep apnea syndrome patients without comorbidities: Focus on the fractionation of executive functions

Author Borges, Juliane Goldoni Autor UNIFESP Google Scholar
Ginani, Giuliano Emerenciano Autor UNIFESP Google Scholar
Hachul, Helena Autor UNIFESP Google Scholar
Cintra, Fatima Dumas Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Pompeia, Sabine Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: Obstructive sleep apnea syndrome (OSAS) is associated with impaired cognition, especially executive functions. However, various of its comorbid conditions are also known to cause cognitive impairment, so it is unclear whether OSAS itself is responsible for cognitive deficits. Our aim was to determine the effects of OSAS on executive functions in otherwise healthy patients. Method: This was a parallel group design study, which involved 22 patients aged 36-65 years diagnosed with moderate to severe OSAS, whose body mass index was below 26, and who did not have diabetes, hypertension, or depression. Controls were 22 healthy individuals with similar age, gender, intelligence quotient, and schooling to those of the patients. Participants completed a test battery that included measures of 6 distinct executive domains (shifting, inhibition, updating, dual-task performance, planning, and access to long-term memory), of all subsystems of the multiple-component working memory model, attention, and mood. Results: OSAS and controls were equivalent in all demographic variables and test scores. the apnea-hypopnea index did not significantly correlate with executive performance, but mean oxygen saturation did so with measurements of executive shifting and access to long-term memory. Conclusions: OSAS without comorbidities did not lead to cognitive impairment.
Keywords Obstructive sleep apnea syndrome
Executive functions
Working memory
Cognitive impairment
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 1998/14303-3
Date 2013-12-01
Published in Journal of Clinical and Experimental Neuropsychology. Philadelphia: Taylor & Francis Inc, v. 35, n. 10, p. 1094-1107, 2013.
ISSN 1380-3395 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Inc
Extent 1094-1107
Origin http://dx.doi.org/10.1080/13803395.2013.858661
Access rights Closed access
Type Article
Web of Science ID WOS:000328108000009
URI http://repositorio.unifesp.br/handle/11600/37053

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