Association of high post-transplant soluble CD30 serum levels with, chronic allograft nephropathy

Association of high post-transplant soluble CD30 serum levels with, chronic allograft nephropathy

Author Grenzi, Patricia C. Autor UNIFESP Google Scholar
Campos, Erika F. Autor UNIFESP Google Scholar
Tedesco-Silva, Helio Google Scholar
Felipe, Claudia R. Google Scholar
Franco, Marcello F. Autor UNIFESP Google Scholar
Soares, Maria Fernanda Sanches Autor UNIFESP Google Scholar
Medina-Pestana, Jose Osmar Autor UNIFESP Google Scholar
Gerbase-DeLima, Maria Autor UNIFESP Google Scholar
Institution AFIP
Universidade Federal de São Paulo (UNIFESP)
Hosp Rim & Hipertensao
Univ Fed Parana
Abstract The purpose of this study was to evaluate the association of post-transplant soluble CD30 (sCD30) levels, isolated or in combination with of anti-HLA class II antibodies and of serum creatinine levels, with kidney graft loss due to chronic allograft nephropathy (CAN), and type of lesions in graft biopsies for cause. the study comprised 511 first kidney graft recipients, transplanted at a single center, with a graft functioning for at least 2.8 years. A single blood sample was collected from each patient sCD30 levels were determined by ELISA, and HIA antibodies by Luminex assay. the minimum follow-up after testing was 93 years. High sCD30 levels, set at sCD30 >= 3.415 ng/mL, the presence of HLA class II antibodies, and serum creatinine >= 1.9 mg/dL were independently associated with CAN-graft loss (P values <0.0001, 0.05, <0.0001, respectively), and the combined hazard ratio for CAN-graft loss was 20.2. Analyses of 166 biopsies for cause showed that high sCD30 levels and creatinine were independently associated with interstitial lesions. Post-transplant sCD30 serum levels, especially in conjunction with information regarding HLA class II antibodies and serum creatinine levels, provide valuable information regarding graft outcome and could be useful for the management of kidney transplant recipients. (C) 2013 Elsevier B.V. All rights reserved.
Keywords Soluble CD30
Chronic allograft nephropathy
Alloantibodies
Kidney transplantation
Post-transplant monitoring
Immunologic monitoring
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2008/56110-0
Date 2013-12-01
Published in Transplant Immunology. Amsterdam: Elsevier B.V., v. 29, n. 1-4, p. 34-38, 2013.
ISSN 0966-3274 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 34-38
Origin http://dx.doi.org/10.1016/j.trim.2013.07.003
Access rights Closed access
Type Article
Web of Science ID WOS:000329145600007
URI http://repositorio.unifesp.br/handle/11600/37047

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