Do sleep abnormalities and misaligned sleep/circadian rhythm patterns represent early clinical characteristics for developing psychosis in high risk populations?

Do sleep abnormalities and misaligned sleep/circadian rhythm patterns represent early clinical characteristics for developing psychosis in high risk populations?

Author Zanini, Marcio Autor UNIFESP Google Scholar
Castro, Juliana Autor UNIFESP Google Scholar
Coelho, Fernando Morgadinho Autor UNIFESP Google Scholar
Bittencourt, Lia Autor UNIFESP Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Sleep architecture changes, such as slow-wave sleep (SWS) percentage variations and reductions in latency and density of rapid eye movement (REM), are found in most patients with schizophrenia and are considered to be an important part of the pathophysiology of the disorder. in addition to these sleep parameters changes, disruptions in sleep homeostasis and the sleep/circadian rhythm also occur in these patients. Sleep/circadian rhythm abnormalities negatively affect neocortical plasticity and cognition and often precede the diagnosis of the illness. Thus, it has been suggested that the sleep/circadian rhythm might be involved in the pathophysiology of psychosis.Recent advances in the identification of individuals at a high risk for developing schizophrenia allow us to investigate several neurobiological processes involved in the development of psychosis. in this article, we review the current evidence of the effects of sleep parameter abnormalities, disruptions in sleep homeostasis and misalignments of sleep circadian rhythm on the early stages of schizophrenia. in addition, we discuss the preliminary evidence of sleep and circadian rhythm abnormalities during the prodromal stages of psychosis and propose that these abnormalities can be explored as potential predictors, as an adjunct to clinical diagnosis, of developing a psychotic disorder in at risk populations. (C) 2013 Elsevier B.V. All rights reserved.
Keywords Schizophrenia
Psychosis
Ultra High Risk
Sleep
Circadian rhythm
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2013-12-01
Published in Neuroscience and Biobehavioral Reviews. Oxford: Pergamon-Elsevier B.V., v. 37, n. 10, p. 2631-2637, 2013.
ISSN 0149-7634 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 2631-2637
Origin http://dx.doi.org/10.1016/j.neubiorev.2013.08.012
Access rights Closed access
Type Review
Web of Science ID WOS:000330490200016
URI http://repositorio.unifesp.br/handle/11600/37043

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