Obesity Modulates the Immune Response to Oxidized LDL in Hypertensive Patients

Obesity Modulates the Immune Response to Oxidized LDL in Hypertensive Patients

Author Fonseca, Henrique Andrade R. Autor UNIFESP Google Scholar
Fonseca, Francisco A. Autor UNIFESP Google Scholar
Monteiro, Andrea M. Google Scholar
Bianco, Henrique T. Autor UNIFESP Google Scholar
Boschcov, Paulo Autor UNIFESP Google Scholar
Brandao, Sergio A. Autor UNIFESP Google Scholar
Juliano, Luiz Autor UNIFESP Google Scholar
Gidlund, Magnus Google Scholar
Izar, Maria C. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Natl Inst Complex Fluids
Universidade de São Paulo (USP)
Natl Inst Nanomat Integrated Markers
Abstract Obesity and hypertension have been recognized as inflammatory diseases capable of activating the immune system, thus contributing to an increased cardiovascular risk. However, the link between adaptive immunity, obesity, and hypertension is poorly understood. We investigated the relationship of the body mass index (BMI) on the inflammatory, vascular, and immune responses in patients with hypertension na < ve of anti-hypertensive treatment. Hypertensive patients (N = 88) were divided into three groups: normal weight (NW), overweight (OW), and obese (OB) subjects. Anti-oxidized LDL autoantibodies (anti-oxLDL Abs), anti-ApoB-D peptide (anti-ApoB-D) Abs, interleukin (IL)-8 and IL-10, flow-mediated dilation (FMD) of the brachial artery, and 24-h ambulatory blood pressure monitoring (ABPM) were assessed. OB patients presented lower levels of anti-oxLDL Abs and IL-10, higher levels of IL-8, and impaired FMD, when compared to NW and OW (P < 0.05), without differences between groups regarding anti-ApoB-D Abs. After adjusting for age, systolic and diastolic blood pressure, anti-oxLDL Abs were inversely correlated with BMI and waist circumference (r = -0.24, P = 0.02 and r = -0.25, P = 0.02, respectively), whereas ApoB-D correlated with 24-h ABPM (r = 0.22, P = 0.05 for systolic, and r = 0.29, P = 0.01 for diastolic blood pressure). Regression analyses showed inverse associations of anti-oxLDL Abs with BMI (beta = -0.05, P = 0.01) and waist circumference (beta = -0.01, P = 0.02); anti-ApoB-D Abs were associated with systolic and diastolic 24-h ABPM (beta = 0.96, P = 0.04; beta = 1.02, P = 0.005, for systolic and diastolic 24-h ABPM, respectively). Among hypertensive patients, obesity modulates the immune and inflammatory milieu, determining an unfavorable balance of cytokines and reduction in titers of anti-oxLDL Abs. Twenty-four hour ABPM is associated with titers of anti-ApoB-D Abs.
Keywords Autoantibodies
Oxidized LDL
Inflammation
Body mass index
Hypertension
Language English
Sponsor National Institute of Complex Fluids, São Paulo, SP, Brazil
Date 2013-12-01
Published in Cell Biochemistry and Biophysics. Totowa: Humana Press Inc, v. 67, n. 3, p. 1451-1460, 2013.
ISSN 1085-9195 (Sherpa/Romeo, impact factor)
Publisher Humana Press Inc
Extent 1451-1460
Origin http://dx.doi.org/10.1007/s12013-013-9585-9
Access rights Closed access
Type Article
Web of Science ID WOS:000327455400071
URI http://repositorio.unifesp.br/handle/11600/37034

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