Effects of sleep deprivation during pregnancy on the reproductive capability of the offspring

Effects of sleep deprivation during pregnancy on the reproductive capability of the offspring

Author Alvarenga, Tathiana A. Autor UNIFESP Google Scholar
Aguiar, Marina F. P. Autor UNIFESP Google Scholar
Mazaro-Costa, Renata Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Gois Goiania
Abstract Objective: To investigate the effects of sleep deprivation during pregnancy on the reproductive capability of the offspring.Design: Using a sleep loss model or control home-cage group (male and females rats) to evaluate sexual behavior and hormonal profile in males and females F1 offispring.Setting: Laboratory.Animals(s): First experiment: Pregnant females were exposed to sleep restriction (SR) protocol and the F1 generation was evaluated. Second experiment: male rats were submitted to SR or paradoxical sleep deprivation (PSD) protocol and the F1 generation was evaluated.Intervention(s): Male and female rats were subjected to sleep restriction (SR) for 21 days or paradoxal sleep-deprived (PSD) for 96 hours.Main Outcome Measure(s): Sexual behavior and hormonal levels during the adult phase were analyzed in F1 offspring of female and male rats submitted to sleep loss.Result(s): F1 male offspring of SR females had lower motivation for sex and reduced progesterone concentrations. in contrast, F1 female offspring displayed significantly enhanced proceptivity compared with control offspring. F1 female offspring also demonstrated hypersexuality by mounting the males in the absence of any significant hormonal alterations. F1 male offspring of SR or paradoxically sleep-deprived (PSD) males presented a decline in the sexual response, accompanied by a reduction in testosterone concentrations. Proceptivity was significantly increased among F1 female offspring of PSD and SR males compared with control offspring.Conclusion(s): SR in progenitors may alter sexual behavior of the F1 offspring in adulthood. These findings reveal far-reaching consequences of sleep deprivation, and suggest that parental sleep influences the reproductive capability of subsequent generations. (Fertil Steril (R) 2013;100:1752-7. (C)2013 by American Society for Reproductive Medicine.)
Keywords Sleep deprivation
pregnancy
sexual behavior
offspring
hormones
rats
Language English
Sponsor Associacao Fundo de Apoio a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
MEC-SeSU (PET) fellowship
Grant number FAPESP: 11/12325-6
FAPESP: 12/05396-7
Date 2013-12-01
Published in Fertility and Sterility. New York: Elsevier B.V., v. 100, n. 6, p. 1752-1757, 2013.
ISSN 0015-0282 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1752-1757
Origin http://dx.doi.org/10.1016/j.fertnstert.2013.08.014
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000327533000050
URI http://repositorio.unifesp.br/handle/11600/36996

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