Interplay between apoptosis and autophagy, a challenging puzzle: New perspectives on antitumor chemotherapies

Interplay between apoptosis and autophagy, a challenging puzzle: New perspectives on antitumor chemotherapies

Author Bincoletto, C. Autor UNIFESP Google Scholar
Bechara, A. Autor UNIFESP Google Scholar
Pereira, G. J. S. Autor UNIFESP Google Scholar
Santos, C. P. Autor UNIFESP Google Scholar
Antunes, F. Autor UNIFESP Google Scholar
da-Silva, J. Peixoto Autor UNIFESP Google Scholar
Muler, M. Autor UNIFESP Google Scholar
Gigli, R. D. Autor UNIFESP Google Scholar
Monteforte, P. T. Autor UNIFESP Google Scholar
Hirata, H. Autor UNIFESP Google Scholar
Jurkiewicz, A. Autor UNIFESP Google Scholar
Smaili, Soraya Soubhi Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Autophagy is a mechanism of protection against various forms of human diseases, such as cancer, in which autophagy seems to have an extremely complex role. in cancer, there is evidence that autophagy may be oncogenic in some contexts, whereas in others it clearly contributes to tumor suppression. in addition, studies have demonstrated the existence of a complex relationship between autophagy and cell death, determining whether a cell will live or die in response to anticancer therapies. Nevertheless, we still need to complete the autophagy-apoptosis puzzle in the tumor context to better address appropriate chemotherapy protocols with autophagy modulators. Generally, tumor cell resistance to anticancer induced-apoptosis can be overcome by autophagy inhibition. However, when an extensive autophagic stimulus is activated, autophagic cell death is observed. in this review, we discuss some details of autophagy and its relationship with tumor progression or suppression, as well as role of autophagy-apoptosis in cancer treatments. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Keywords Autophagy
Cell death
Anticancer therapies
Metastasis
Drug resistance
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 12/51215-4
Date 2013-11-25
Published in Chemico-biological Interactions. Clare: Elsevier B.V., v. 206, n. 2, p. 279-288, 2013.
ISSN 0009-2797 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 279-288
Origin http://dx.doi.org/10.1016/j.cbi.2013.09.018
Access rights Closed access
Type Review
Web of Science ID WOS:000328523100020
URI http://repositorio.unifesp.br/handle/11600/36989

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