Evaluation of cerebral electrical activity and cardiac output after patent ductus arteriosus ligation in preterm infants

Evaluation of cerebral electrical activity and cardiac output after patent ductus arteriosus ligation in preterm infants

Author Leslie, A. T. F. S. Autor UNIFESP Google Scholar
Jain, A. Google Scholar
EL-Khuffash, A. Google Scholar
Keyzers, M. Google Scholar
Rogerson, S. Google Scholar
McNamara, P. J. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Toronto
Rotunda Hosp
Univ Melbourne
Hosp Sick Children
Abstract OBJECTIVE: To characterize and investigate the relationship between systemic blood flow and pre- and postoperative cerebral electrical activity in preterm neonates undergoing patent ductus arteriosus (PDA) ligation.STUDY DESIGN: A prospective observational study was conducted in 17 preterm neonates undergoing PDA ligation. All infants had amplitude-integrated electroencephalography (aEEG) recorded continuously from 4 h preoperatively to 24 h postoperatively. Targeted neonatal echocardiography was performed to evaluate myocardial performance and systemic blood flow at four sequential time points: preoperatively; 1, 8 and 24 h postoperatively.RESULT: PDA ligation was followed by a fall in the lower border of the aEEG trace lower left ventricular output, but recovery of diastolic flow in the middle cerebral artery. Altered lower margin was associated with gestational age and PDA diameter on univariate analysis, but not with low cardiac output.CONCLUSION: PDA ligation was associated with altered cerebral electrical activity, although these changes were not related to low cardiac output state.
Keywords aEEG
infant
PDA ligation
upper and lower margins
echocardiography
cardiac output
Language English
Date 2013-11-01
Published in Journal of Perinatology. New York: Nature Publishing Group, v. 33, n. 11, p. 861-866, 2013.
ISSN 0743-8346 (Sherpa/Romeo, impact factor)
Publisher Nature Publishing Group
Extent 861-866
Origin http://dx.doi.org/10.1038/jp.2013.85
Access rights Closed access
Type Article
Web of Science ID WOS:000326503500009
URI http://repositorio.unifesp.br/handle/11600/36957

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