Autophagy as a Neuroprotective Mechanism Against 3-Nitropropionic Acid-Induced Murine Astrocyte Cell Death

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dc.contributor.author Pereira, Gustavo J. S. [UNIFESP]
dc.contributor.author Tressoldi, Nicole [UNIFESP]
dc.contributor.author Hirata, Hanako [UNIFESP]
dc.contributor.author Bincoletto, Claudia [UNIFESP]
dc.contributor.author Smaili, Soraya Soubhi [UNIFESP]
dc.date.accessioned 2016-01-24T14:34:39Z
dc.date.available 2016-01-24T14:34:39Z
dc.date.issued 2013-11-01
dc.identifier http://dx.doi.org/10.1007/s11064-013-1154-5
dc.identifier.citation Neurochemical Research. New York: Springer/plenum Publishers, v. 38, n. 11, p. 2418-2426, 2013.
dc.identifier.issn 0364-3190
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36930
dc.description.abstract Huntington's disease (HD) is a genetic neurodegenerative disorder that is characterized by severe striatal atrophy with extensive neuronal loss and gliosis. Although the molecular mechanism is not well understood, experimental studies use the irreversible mitochondrial inhibitor 3-nitropropionic acid (3-NP) to mimic the neuropathological features of HD. in this study, the role of autophagy as a neuroprotective mechanism against 3-NP-induced astrocyte cytotoxicity was evaluated. Autophagy is a catabolic process that is essential for the turnover of cytosolic proteins and organelles and is involved in the modulation of cell death and survival. We showed that 3-NP-induced apoptosis, which was accompanied by Bax and Beclin-1 upregulation, was dependent on acidic vesicular organelle (AVO) formation after a continuous exposure to 3-NP for 12 h. the upregulation of Bax and Beclin-1 as well as AVO formation were normalized 24 h after 3-NP exposure. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 2418-2426
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Neurochemical Research
dc.rights Acesso restrito
dc.subject Huntington's disease en
dc.subject 3-Nitropropionic acid en
dc.subject Apoptosis en
dc.subject Autophagy en
dc.title Autophagy as a Neuroprotective Mechanism Against 3-Nitropropionic Acid-Induced Murine Astrocyte Cell Death en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Fed Univ São Paulo UNIFESP, Dept Pharmacol, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifesp Fed Univ São Paulo UNIFESP, Dept Pharmacol, BR-04044020 São Paulo, Brazil
dc.identifier.doi 10.1007/s11064-013-1154-5
dc.description.source Web of Science
dc.identifier.wos WOS:000325704400020



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