Effect of co-transporter blockers on non-synaptic epileptiform activity-computational simulation

Effect of co-transporter blockers on non-synaptic epileptiform activity-computational simulation

Author Lopes, Mariana Rodrigues Google Scholar
Canton Santos, Luiz Eduardo Google Scholar
Rodrigues, Antonio Marcio Google Scholar
Duarte, Mario Antonio Google Scholar
Catelli Infantosi, Antonio Fernando Google Scholar
Scorza, Fulvio Alexandre Autor UNIFESP Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Madureira, Ana Paula Google Scholar
Silveira, Gilcelio Amaral da Google Scholar
Santos, Ivans Carlos dos Google Scholar
Cavalheiro, Esper Abrao Autor UNIFESP Google Scholar
Almeida, Antonio-Carlos Guimaraes de Google Scholar
Institution Univ Fed Sao Joao del Rei
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Abstract The important role of cation-chloride co-transporters in epilepsy is being supported by an increasing number of investigations. However, enormous complexity is involved since the action of these co-transporters has effects on the ionic homeostasis influencing directly the neuronal excitability and the tissue propensity to sustain seizure. To unravel the complex mechanisms involving the co-transporters action during seizure, this paper shows simulations of non-synaptic epileptiform activity and the effect of the blockage of the two different types of cation-chloride co-transporters present in the brain: Na, K and 2Cl co-transporter (NKCC) and K and Cl co-transporter (KCC). the simulations were performed with an electrochemical model representing the non-synaptic structure of the granule cell layer of the dentate gyrus (DG) of the rat hippocampus. the simulations suggest: (i) the potassium clearance is based on the systemic interplay between the Na/K pump and the NKCC co-transporters; (ii) the simultaneous blockage of the NKCC of the neurons and KCC of glial cells acts efficiently suppressing the epileptiform activities; and (iii) the simulations show that depending on the combined blockage of the co-transporters, the epileptiform activities may be suppressed or enhanced.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2013-10-01
Published in Physical Biology. Bristol: Iop Publishing Ltd, v. 10, n. 5, 16 p., 2013.
ISSN 1478-3967 (Sherpa/Romeo, impact factor)
Publisher Iop Publishing Ltd
Extent 16
Origin http://dx.doi.org/10.1088/1478-3975/10/5/056008
Access rights Closed access
Type Article
Web of Science ID WOS:000325618400008
URI http://repositorio.unifesp.br/handle/11600/36848

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