Hippocampal atrophy and memory dysfunction in patients with juvenile myoclonic epilepsy

Hippocampal atrophy and memory dysfunction in patients with juvenile myoclonic epilepsy

Author Lin, Katia Autor UNIFESP Google Scholar
Araujo Filho, Gerardo Maria de Autor UNIFESP Google Scholar
Pascalicchio, Tatiana Frascareli Autor UNIFESP Google Scholar
Silva, Ivaldo Autor UNIFESP Google Scholar
Silva Tudesco, Ivanda Souza Autor UNIFESP Google Scholar
Bittar Guaranha, Mirian Salvadori Autor UNIFESP Google Scholar
Carrete Junior, Henrique Autor UNIFESP Google Scholar
Jackowski, Andrea Parolin Autor UNIFESP Google Scholar
Targas Yacubian, Elza Marcia Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Juvenile myoclonic epilepsy (JME) is a well-defined idiopathic generalized epilepsy (IGE) syndrome, being the most common IGE in adults and accounting for 5-11% of patients with epilepsy. While neuropsychological and neuroimaging studies have discussed the thalamofrontal dysfunction as the major pathophysiologic mechanism of JME, investigation on memory is scarce in patients with JME, with lack of objective assessments addressing common complaints and daily difficulties such as recalling telephone numbers, messages to pass on, and taking antiepileptic drugs regularly. the aim of this study was to objectively assess memory deficits in a group of patients with JME using neuropsychological examination combined with structural MRI of the hippocampi. After informed consent, a cohort of 56 consecutive patients with JME (29 males; mean age +/- SD = 26.5 +/- 9.01 years; range = 14.0-55.0 years) was included. the control group consisted of 42 healthy volunteers (18 males; mean age +/- SD = 31.0 +/- 8.54 years; range = 20.0-56.0 years) without a family history of neuropsychiatric disorders. Patients and controls were submitted to a MRI and to a neuropsychological assessment, and comparisons between groups were performed, as well as a correlation study between hippocampal atrophy and neuropsychological performance in a group of patients with JME. the level of statistical significance was set at p < 0.05. Significant hippocampal atrophy among patients with JME was observed, which was correlated with memory dysfunctions. the present findings reinforce the existence of functional-anatomic ictogenic networks that are not limited to frontal lobes, providing further support towards the concept of 'system epilepsies' in JME. (C) 2013 Elsevier Inc. All rights reserved.
Keywords Juvenile myoclonic epilepsy
Memory dysfunctions
Hippocampal atrophy
Magnetic resonance imaging
Neuropsychological testing
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2013-10-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 29, n. 1, p. 247-251, 2013.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 247-251
Origin http://dx.doi.org/10.1016/j.yebeh.2013.06.034
Access rights Closed access
Type Article
Web of Science ID WOS:000324241300042
URI http://repositorio.unifesp.br/handle/11600/36842

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