Cardiovascular autonomic dysfunction in non-obese diabetic mice

Cardiovascular autonomic dysfunction in non-obese diabetic mice

Author Moraes, Oscar A. Google Scholar
Colucci, Juliana A. Autor UNIFESP Google Scholar
Souza, Leandro E. Google Scholar
Scapini, Katia B. Google Scholar
Moraes-Silva, Ivana C. Google Scholar
Mostarda, Cristiano Google Scholar
De Angelis, Katia Google Scholar
Casarini, Dulce E. Autor UNIFESP Google Scholar
Irigoyen, Maria Claudia Google Scholar
Institution Universidade de São Paulo (USP)
Nove de Julho Univ
Universidade Federal de São Paulo (UNIFESP)
Univ Fed Maranhao
Abstract It is known that diabetes is associated with autonomic dysfunction; however, data about autonomic function in non-obese diabetic mice (NOD) remain scarce. We evaluated the autonomic profile of NOD mice. Female mice, 24-28 week old, were divided in two groups: NOD (n = 6) and control (n = 6, Swiss mice). NOD mice with glycemia >= 300 mg/dl were used. Heart rate variability (HRV) and arterial pressure variability (APV) in time and frequency domains, symbolic analysis of heart rate (HR) and baroreflex sensitivity were evaluated. HR and arterial pressure (AP) were similar between the groups; however, HRV (total variance of RR interval: NOD = 21.07 +/- 3.75 vs. C = 42.02 +/- 6.54 ms(2)) and the vagal modulation index RMSSD were lower in NOD group (4.01 +/- 032 vs. 8.28 +/- 0.97 ms). Moreover, the absolute and normalized low-frequency (LF) components were also enhanced in NOD (normalized = 61.0 +/- 4.0%) as compared to control mice (normalized = 20.0 +/- 4.0%). Both the absolute and normalized high-frequency (HF) components were lower in NOD (normalized = 39.0 +/- 4.0%) when compared to the control group (normalized = 80.0 +/- 4.0). in the symbolic analysis the 0V pattern, an indication of sympathetic activity, was higher in NOD and 2LV pattern, an indication of parasympathetic activity, was lower in the NOD than in the control group. Both bradycardic and tachycardic responses were decreased in NOD (3.01 +/- 0.72 vs. 4.54 +/- 0.36 bpm/mm Hg and 2.49 +/- 031 vs. C = 3.43 +/- 033 bpm/mm Hg) when compared to the control group. Correlation analysis showed negative correlations between vagal indexes (RMSSD, %HF and 2LV) and glycemic levels. in conclusion, NOD mice develop severe diabetes correlated with autonomic dysfunction. (C) 2013 Elsevier B.V. All rights reserved.
Keywords Diabetes mellitus
Autonomic nervous system
Inbred NOD
Language English
Date 2013-10-01
Published in Autonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 177, n. 2, p. 143-147, 2013.
ISSN 1566-0702 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 143-147
Access rights Closed access
Type Article
Web of Science ID WOS:000325665700011

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