The anti-inflammatory potential of phenolic compounds in grape juice concentrate (G8000 (TM)) on 2,4,6-trinitrobenzene sulphonic acid-induced colitis

The anti-inflammatory potential of phenolic compounds in grape juice concentrate (G8000 (TM)) on 2,4,6-trinitrobenzene sulphonic acid-induced colitis

Author Ribeiro Paiotti, Ana Paula Autor UNIFESP Google Scholar
Neto, Ricardo Artigiani Autor UNIFESP Google Scholar
Marchi, Patricia Autor UNIFESP Google Scholar
Silva, Roseane Mendes Autor UNIFESP Google Scholar
Pazine, Vanessa Lima Autor UNIFESP Google Scholar
Noguti, Juliana Autor UNIFESP Google Scholar
Pastrelo, Mauricio Mercaldi Autor UNIFESP Google Scholar
Boiago Golluecke, Andrea Pittelli Google Scholar
Miszputen, Sender Jankiel Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Abstract Chronic inflammatory bowel disease is characterised by an up-regulation of the synthesis and release of a variety of pro-inflammatory mediators leading to excessive tissue injury. Flavonoids are able to inhibit enzymes and/or due to their antioxidant properties regulate the immune response. the goal of the present study was to evaluate the mechanisms of action of phenolic compounds present in grape juice on 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis. A total of forty-one male Wistar rats were randomised into seven groups: negative control group; TNBS non-treated induced colitis; 2% grape juice control group; 1% grape juice 24 h after TNBS colitis induction; 1% grape juice on day 7 after colitis induction; 2% grape juice 24 h after colitis induction; 2% grape juice on day 7 after colitis induction. the 1% grape juice-treated induced colitis group showed marked clinical improvement when compared with the TNBS-induced colitis group. Rats that received 1% grape juice, on day 7 after colitis induction, presented reduced intensity of macroscopic and histological scores. Statistically significant differences (P<0.05) of TNF-alpha and inducible NO synthase mRNA expression were detected in the groups treated with grape juice at the 1% dose after inducing experimental colitis when compared with the TNBS group. Grape juice reduced the noxious effects induced by colitis caused by TNBS, especially at the 1% dose.
Keywords 2,4,6-Trinitrobenzene sulphonic acid-induced colitis
Grape juice
Inducible nitric oxide synthase
Intercellular adhesion molecule-1
NF-kappa B
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2013-09-28
Published in British Journal of Nutrition. Cambridge: Cambridge Univ Press, v. 110, n. 6, p. 973-980, 2013.
ISSN 0007-1145 (Sherpa/Romeo, impact factor)
Publisher Cambridge Univ Press
Extent 973-980
Access rights Closed access
Type Article
Web of Science ID WOS:000323848700001

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