Cognitive, motor and tyrosine hydroxylase temporal impairment in a model of parkinsonism induced by reserpine

Cognitive, motor and tyrosine hydroxylase temporal impairment in a model of parkinsonism induced by reserpine

Author Santos, Jose R. Google Scholar
Cunha, Joao A. S. Google Scholar
Dierschnabel, Aline L. Google Scholar
Campelo, Clarissa L. C. Google Scholar
Leao, Anderson H. F. F. Google Scholar
Silva, Anatildes F. Google Scholar
Engelberth, Rovena C. G. J. Google Scholar
Izidio, Geison S. Google Scholar
Cavalcante, Jeferson S. Google Scholar
Abilio, Vanessa C. Autor UNIFESP Google Scholar
Ribeiro, Alessandra M. Google Scholar
Silva, Regina H. Google Scholar
Institution Univ Fed Rio Grande do Norte
Universidade Federal de Santa Catarina (UFSC)
Universidade Federal de São Paulo (UNIFESP)
Abstract Studies have suggested that cognitive deficits can precede motor alterations in Parkinson's disease (PD). However, in general, classic animal models are based on severe motor impairment after one single administration of neurotoxins, and thereby do not express the progressive nature of the pathology. A previous study showed that the repeated administration with a low dose (0.1 mg/kg) of the monoamine depleting agent reserpine induces a gradual appearance of motor signs of pharmacological parkinsonism in rats. Here, we showed this repeated treatment with reserpine induced a memory impairment (evaluated by the novel object recognition task) before the gradual appearance of the motor signs. Additionally, these alterations were accompanied by decreased tyrosine hydroxylase (TH) striatal levels and reduced number of TH+ cells in substantia nigra pars compacta (SNpc). After 30 days without treatment, reserpine-treated animals showed normal levels of striatal TH, partial recovery of TH+ cells in SNpc, recovery of motor function, but not reversal of the memory impairment. Furthermore, the motor alterations were statistically correlated with decreased TH levels (GD, CA1, PFC and DS) and number of TH+ cells (SNpc and VTA) in the brain. Thus, we extended previous results showing that the gradual appearance of motor impairment induced by repeated treatment with a low dose of reserpine is preceded by short-term memory impairment, as well as accompanied by neurochemical alterations compatible with the pathology of PD. (C) 2013 Elsevier B.V. All rights reserved.
Keywords Reserpine
Parkinson's disease
Memory
Movement disorders
Animal model
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundacao de Apoio Pesquisa do Estado do Rio Grande do Norte (FAPERN)
Pro-reitoria de Pesquisa da Universidade Federal do Rio Grande do Norte (PROPESQ/UFRN)
Date 2013-09-15
Published in Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 253, p. 68-77, 2013.
ISSN 0166-4328 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 68-77
Origin http://dx.doi.org/10.1016/j.bbr.2013.06.031
Access rights Closed access
Type Article
Web of Science ID WOS:000324720500010
URI http://repositorio.unifesp.br/handle/11600/36754

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