Aerobic exercise attenuates inhibitory avoidance memory deficit induced by paradoxical sleep deprivation in rats

Aerobic exercise attenuates inhibitory avoidance memory deficit induced by paradoxical sleep deprivation in rats

Author Fernandes, Jansen Autor UNIFESP Google Scholar
Zaccaro Baliego, Luiz Guilherme Autor UNIFESP Google Scholar
Peixinho-Pena, Luiz Fernando Autor UNIFESP Google Scholar
Almeida, Alexandre Aparecido de Autor UNIFESP Google Scholar
Venancio, Daniel Paulino Autor UNIFESP Google Scholar
Scorza, Fulvio Alexandre Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The deleterious effects of paradoxical sleep deprivation (SD) on memory processes are well documented. Physical exercise improves many aspects of brain functions and induces neuroprotection. in the present study, we investigated the influence of 4 weeks of treadmill aerobic exercise on both long-term memory and the expression of synaptic proteins (GAP-43, synapsin I, synaptophysin, and PSD-95) in normal and sleep-deprived rats. Adult Wistar rats were subjected to 4 weeks of treadmill exercise training for 35 min, five times per week. Twenty-four hours after the last exercise session, the rats were sleep-deprived for 96 h using the modified multiple platform method. To assess memory after SD, all animals underwent training for the inhibitory avoidance task and were tested 24 h later. the aerobic exercise attenuated the long-term memory deficit induced by 96 h of paradoxical SD. Western blot analysis of the hippocampus revealed increased levels of GAP-43 in exercised rats. However, the expression of synapsin I, synaptophysin, and PSD-95 was not modified by either exercise or SD. Our results suggest that an aerobic exercise program can attenuate the deleterious effects of SD on long-term memory and that this effect is not directly related to changes in the expression of the pre- and post-synaptic proteins analyzed in the study. (C) 2013 Elsevier B.V. All rights reserved.
Keywords Sleep deprivation
Treadmill exercise
Memory
Synaptic proteins
Hippocampus
Neuroplasticity
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
CEPE
CEMSA
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
INNT (Brazil)
Date 2013-09-05
Published in Brain Research. Amsterdam: Elsevier B.V., v. 1529, p. 66-73, 2013.
ISSN 0006-8993 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 66-73
Origin http://dx.doi.org/10.1016/j.brainres.2013.07.019
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000324658200007
URI http://repositorio.unifesp.br/handle/11600/36743

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