Oxidative stress, cancer, and sleep deprivation: is there a logical link in this association?

Oxidative stress, cancer, and sleep deprivation: is there a logical link in this association?

Author Noguti, Juliana Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Cirelli, Chiara Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Wisconsin
Abstract Sleep disorders are associated with various human pathologies and interfere with biological processes essential for health and quality of life. On the other hand, cancer is one of the most common diseases worldwide with an average of 1,500 deaths per day in the USA. Is there a factor common to both sleep disorders and cancer that serves to link these conditions?It is a normal process for cellular metabolism to produce reactive oxidant series (ROS). However, when the production of ROS overcomes the antioxidant capacity of the cell to eliminate these products, the resulting state is called oxidative stress. Oxidative DNA damage may participate in ROS-induced carcinogenesis. Moreover, ROS are also produced in the sleep deprivation process. the aim of this article is to review pathways and mechanisms that may point to oxidative stress as a link between sleep deprivation and cancer.
Keywords Sleep deprivation
Oxidative stress
Language English
Date 2013-09-01
Published in Sleep and Breathing. Heidelberg: Springer Heidelberg, v. 17, n. 3, p. 905-910, 2013.
ISSN 1520-9512 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 905-910
Origin http://dx.doi.org/10.1007/s11325-012-0797-9
Access rights Closed access
Type Review
Web of Science ID WOS:000323259300005
URI http://repositorio.unifesp.br/handle/11600/36703

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