Effectiveness of Trimethoprim-Sulfamethoxazole and Metronidazole in the Treatment of Small Intestinal Bacterial Overgrowth in Children Living in a Slum

Effectiveness of Trimethoprim-Sulfamethoxazole and Metronidazole in the Treatment of Small Intestinal Bacterial Overgrowth in Children Living in a Slum

Author Tahan, Soraia Autor UNIFESP Google Scholar
Melli, Ligia Cristina F. L. Google Scholar
Mello, Carolina Santos Google Scholar
Rodrigues, Mirian Silva C. Google Scholar
Bezerra Filho, Humberto Google Scholar
Morais, Mauro B. de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fdn Educ Osasco
Abstract Trimethoprim-sulfamethoxazole and metronidazole were used for 14 days to treat 20 children with small intestine bacterial overgrowth (SIBO). SIBO was diagnosed using the lactulose hydrogen breath test. the breath test was repeated 1 month after treatment, and 19 (95.0%) of 20 children showed no evidence of SIBO (P<0.001). the area under the individual curves showed that children with SIBO exhibited greater hydrogen production before treatment in both the first hour and between 60 and 180 minutes after the breath test. the treatment did not decrease methane production. in conclusion, trimethoprim-sulfamethoxazole and metronidazole was effective in treating children with SIBO.
Keywords antibiotic
children
hydrogen
methane breath test
small intestinal bacterial overgrowth
Language English
Date 2013-09-01
Published in Journal of Pediatric Gastroenterology and Nutrition. Philadelphia: Lippincott Williams & Wilkins, v. 57, n. 3, p. 316-318, 2013.
ISSN 0277-2116 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 316-318
Origin http://dx.doi.org/10.1097/MPG.0b013e3182952e93
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000326745200017
URI http://repositorio.unifesp.br/handle/11600/36670

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