Amniotic membrane transplantation versus anterior stromal puncture in bullous keratopathy: a comparative study

Amniotic membrane transplantation versus anterior stromal puncture in bullous keratopathy: a comparative study

Author Paris, Fabiana dos Santos Autor UNIFESP Google Scholar
Goncalves, Eliana Domingues Autor UNIFESP Google Scholar
Queiroz Campos, Mauro Silveira de Autor UNIFESP Google Scholar
Sato, Elcio Hideo Autor UNIFESP Google Scholar
Dua, Harminder S. Google Scholar
Gomes, José Álvaro Pereira Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Nottingham
Abstract PurposeTo compare amniotic membrane transplantation (AMT) and anterior stromal puncture (ASP) in the management of pain in patients with symptomatic bullous keratopathy (BK).MethodsIn this prospective comparative study, 40 eyes of 40 patients with symptomatic BK (chronic intermittent pain) were randomised and divided into two groups (AMT and ASP) according to the technique used to treat symptomatic BK. the patients were examined on days 1, 14, 30, 90 and 180 postoperatively. Patients with BK under the age of 18 with raised eye pressure, concurrent ocular surface infection and those without any pain were excluded.ResultsAt follow-up at 90 and 180days the presence of a regular epithelial surface was higher in the AMT group (60% and 50%, respectively) than in the ASP group (16.7% and 6. 3%, p=0.006 and p=0.008, respectively). At 180days follow-up there was no statistical difference between the two groups in the severity (p=0.391) or duration (p=0.715) of pain.ConclusionsAMT is similar to ASP in the relief of pain in symptomatic BK. However, ASP is a simple outpatient procedure and should cost less than AMT. NCT 00659308
Keywords Cornea
Ocular surface
Treatment Surgery
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2001/07036-3
Date 2013-08-01
Published in British Journal of Ophthalmology. London: Bmj Publishing Group, v. 97, n. 8, p. 980-984, 2013.
ISSN 0007-1161 (Sherpa/Romeo, impact factor)
Publisher Bmj Publishing Group
Extent 980-984
Access rights Closed access
Type Article
Web of Science ID WOS:000322039400009

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