Undervaccination of Perinatally HIV-infected and HIV-exposed Uninfected Children in Latin America and the Caribbean

Undervaccination of Perinatally HIV-infected and HIV-exposed Uninfected Children in Latin America and the Caribbean

Author Succi, Regina C. M. Autor UNIFESP Google Scholar
Krauss, Margot R. Google Scholar
Harris, D. Robert Google Scholar
Machado, Daisy M. Autor UNIFESP Google Scholar
Moraes-Pinto, Maria Isabel de Autor UNIFESP Google Scholar
Mussi-Pinhata, Marisa M. Google Scholar
Pavia Ruz, Noris Google Scholar
Pierre, Russell B. Google Scholar
Kolevic, Lenka Google Scholar
Joao, Esau Google Scholar
Foradori, Irene Google Scholar
Hazra, Rohan Google Scholar
Siberry, George K. Google Scholar
NISDI Pediat Study Grp 2012 Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Westat Corp
Universidade de São Paulo (USP)
Hosp Infantil Mexico Dr Federico Gomez
Univ W Indies
Natl Univ San Marcos Lima
Hosp Fed Servidores Estado
Univ Buenos Aires
Eunice Kennedy Shriver Natl Inst Child Hlth & Hum
Abstract Background: Perinatally HIV-infected (PHIV) children may be at risk of undervaccination. Vaccination coverage rates among PHIV and HIV-exposed uninfected (HEU) children in Latin America and the Caribbean were compared.Methods: All PHIV and HEU children born from 2002 to 2007 who were enrolled in a multisite observational study conducted in Latin America and the Caribbean were included in this analysis. Children were classified as up to date if they had received the recommended number of doses of each vaccine at the appropriate intervals by 12 and 24 months of age. Fisher's exact test was used to analyze the data. Covariates potentially associated with a child's HIV status were considered in multivariable logistic regression modeling.Results: of 1156 eligible children, 768 (66.4%) were HEU and 388 (33.6%) were PHIV. HEU children were significantly (P < 0.01) more likely to be up to date by 12 and 24 months of age for all vaccines examined. Statistically significant differences persisted when the analyses were limited to children enrolled before 12 months of age. Controlling for birth weight, sex, primary caregiver education and any use of tobacco, alcohol or illegal drugs during pregnancy did not contribute significantly to the logistic regression models.Conclusions: PHIV children were significantly less likely than HEU children to be up to date for their childhood vaccinations at 12 and 24 months of age, even when limited to children enrolled before 12 months of age. Strategies to increase vaccination rates in PHIV are needed.
Keywords pediatric HIV infection
vaccination
Latin America
Language English
Sponsor NICHD
Grant number NICHD: N01-HD-3-3345
NICHD: HHSN267200800001C
NICHD: N01-HD-8-0001
Date 2013-08-01
Published in Pediatric Infectious Disease Journal. Philadelphia: Lippincott Williams & Wilkins, v. 32, n. 8, p. 845-850, 2013.
ISSN 0891-3668 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 845-850
Origin http://dx.doi.org/10.1097/INF.0b013e31828bbe68
Access rights Closed access
Type Article
Web of Science ID WOS:000330524100013
URI http://repositorio.unifesp.br/handle/11600/36619

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