Invasive fungal diseases in haematopoietic cell transplant recipients and in patients with acute myeloid leukaemia or myelodysplasia in Brazil

Invasive fungal diseases in haematopoietic cell transplant recipients and in patients with acute myeloid leukaemia or myelodysplasia in Brazil

Author Nucci, Marcio Google Scholar
Garnica, M. Google Scholar
Gloria, A. B. Google Scholar
Lehugeur, D. S. Google Scholar
Dias, V. C. H. Google Scholar
Palma, L. C. Google Scholar
Cappellano, P. Autor UNIFESP Google Scholar
Fertrin, K. Y. Google Scholar
Carlesse, F. Autor UNIFESP Google Scholar
Simoes, B. Google Scholar
Bergamasco, M. D. Autor UNIFESP Google Scholar
Cunha, C. A. Google Scholar
Seber, Adriana Autor UNIFESP Google Scholar
Ribeiro, M. P. D. Google Scholar
Queiroz-Telles, F. Google Scholar
Lee, Maria Lúcia de Martino Autor UNIFESP Google Scholar
Chauffaille, M. L. Autor UNIFESP Google Scholar
Silla, L. Google Scholar
Souza, C. A. de Google Scholar
Colombo, Arnaldo Lopes Autor UNIFESP Google Scholar
Institution Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de Minas Gerais (UFMG)
Univ Fed Rio Grande do Sul
Universidade Federal do Paraná (UFPR)
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Abstract Invasive fungal disease (IFD) shows distinct regional incidence patterns and epidemiological features depending on the geographic region. We conducted a prospective survey in eight centres in Brazil from May 2007 to July 2009. All haematopoietic cell transplant (HCT) recipients and patients with acute myeloid leukaemia (AML) or myelodysplasia (MDS) were followed from admission until 1year (HCT) or end of consolidation therapy (AML/MDS). the 12-month cumulative incidence (CI) of proven or probable IFD was calculated, and curves were compared using the Grey test. Among 237 AML/MDS patients and 700 HCT recipients (378 allogeneic, 322 autologous), the 1-year CI of IFD in AML/MDS, allogeneic HCT and autologous HCT was 18.7%, 11.3% and 1.9% (p<0.001), respectively. Fusariosis (23 episodes), aspergillosis (20 episodes) and candidiasis (11 episodes) were the most frequent IFD. the 1-year CI of aspergillosis and fusariosis in AML/MDS, allogeneic HCT and autologous HCT were 13.4%, 2.3% and 0% (p<0.001), and 5.2%, 3.8% and 0.6% (p0.01), respectively. the 6-week probability of survival was 53%, and was lower in cases of fusariosis (41%). We observed a high burden of IFD and a high incidence and mortality for fusariosis in this first multicentre epidemiological study of IFD in haematological patients in Brazil.
Keywords Aspergillosis
epidemiology
fusariosis
haematological malignancy
invasive fungal disease
Language English
Sponsor Pfizer Inc.
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number CNPq: 472154/2008-7
CNPq: 301025/2008-8
Date 2013-08-01
Published in Clinical Microbiology and Infection. Hoboken: Wiley-Blackwell, v. 19, n. 8, p. 745-751, 2013.
ISSN 1198-743X (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 745-751
Origin http://dx.doi.org/10.1111/1469-0691.12002
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000321761900020
URI http://repositorio.unifesp.br/handle/11600/36560

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