Acai (Euterpe oleracea Mart.) feeding attenuates dimethylhydrazine-induced rat colon carcinogenesis

Acai (Euterpe oleracea Mart.) feeding attenuates dimethylhydrazine-induced rat colon carcinogenesis

Author Fragoso, Mariana F. Google Scholar
Romualdo, Guilherme R. Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Barbisan, Luis F. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract This study investigated the protective effect of spray-dried gal powder (AP) intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4 weeks of DMH administrations, the groups were fed with standard diet, a diet containing 2.5% or 5.0% AP or a diet containing 0.2% N-acetylcysteine (NAC) for 10 weeks, using aberrant crypt foci (ACF) as the endpoint. Additionally, two groups were fed with standard diet or a diet containing 5.0% AP for 20 weeks, using colon tumors as the endpoint. in ACF assay, a reduction in the number of aberrant crypts (ACs) and ACF (1 similar to 3 AC) were observed in the groups fed with 5.0% AP (37% AC and 47% ACF inhibition, p = 0.036) and 0.2% NAC (39% AC and 41% ACF inhibition, p = 0.042). in tumor assay, a reduction in the number of invasive tumors (p < 0.005) and tumor multiplicity (p = 0.001) was observed in the group fed with 5.0% AP. Also, a reduction in tumor Ki-67 cell proliferation (p = 0.003) and net growth index (p = 0.001) was observed in the group fed with 5.0% AP. Therefore the findings of this study indicate that AP feeding may reduce the development of chemically-induced rat colon carcinogenesis. (C) 2013 Elsevier B.V. All rights reserved.
Keywords Aberrant crypt foci
Spray-dry
Acai pulp
Colon carcinogenesis
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2013-08-01
Published in Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 58, p. 68-76, 2013.
ISSN 0278-6915 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 68-76
Origin http://dx.doi.org/10.1016/j.fct.2013.04.011
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000322099100010
URI http://repositorio.unifesp.br/handle/11600/36558

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