Genome-wide association study identifies two susceptibility loci for osteosarcoma

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dc.contributor.author Savage, Sharon A.
dc.contributor.author Mirabello, Lisa
dc.contributor.author Wang, Zhaoming
dc.contributor.author Gastier-Foster, Julie M.
dc.contributor.author Gorlick, Richard
dc.contributor.author Khanna, Chand
dc.contributor.author Flanagan, Adrienne M.
dc.contributor.author Tirabosco, Roberto
dc.contributor.author Andrulis, Irene L.
dc.contributor.author Wunder, Jay S.
dc.contributor.author Gokgoz, Nalan
dc.contributor.author Patino-Garcia, Ana
dc.contributor.author Sierrasesumaga, Luis
dc.contributor.author Lecanda, Fernando
dc.contributor.author Kurucu, Nilgun
dc.contributor.author Ilhan, Inci Ergurhan
dc.contributor.author Sari, Neriman
dc.contributor.author Serra, Massimo
dc.contributor.author Hattinger, Claudia
dc.contributor.author Picci, Piero
dc.contributor.author Spector, Logan G.
dc.contributor.author Barkauskas, Donald A.
dc.contributor.author Marina, Neyssa
dc.contributor.author Toledo, Silvia Regina Caminada de [UNIFESP]
dc.contributor.author Petrilli, Antonio S. [UNIFESP]
dc.contributor.author Amary, Maria Fernanda
dc.contributor.author Halai, Dina
dc.contributor.author Thomas, David M.
dc.contributor.author Douglass, Chester
dc.contributor.author Meltzer, Paul S.
dc.contributor.author Jacobs, Kevin
dc.contributor.author Chung, Charles C.
dc.contributor.author Berndt, Sonja I.
dc.contributor.author Purdue, Mark P.
dc.contributor.author Caporaso, Neil E.
dc.contributor.author Tucker, Margaret
dc.contributor.author Rothman, Nathaniel
dc.contributor.author Landi, Maria Teresa
dc.contributor.author Silverman, Debra T.
dc.contributor.author Kraft, Peter
dc.contributor.author Hunter, David J.
dc.contributor.author Malats, Nuria
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Wacholder, Sholom
dc.contributor.author Troisi, Rebecca
dc.contributor.author Helman, Lee
dc.contributor.author Fraumeni, Joseph F.
dc.contributor.author Yeager, Meredith
dc.contributor.author Hoover, Robert N.
dc.contributor.author Chanock, Stephen J.
dc.date.accessioned 2016-01-24T14:31:58Z
dc.date.available 2016-01-24T14:31:58Z
dc.date.issued 2013-07-01
dc.identifier http://dx.doi.org/10.1038/ng.2645
dc.identifier.citation Nature Genetics. New York: Nature Publishing Group, v. 45, n. 7, p. 799-+, 2013.
dc.identifier.issn 1061-4036
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36511
dc.description.abstract Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. To better understand the genetic etiology of osteosarcoma, we performed a multistage genome-wide association study consisting of 941 individuals with osteosarcoma (cases) and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: a locus in the GRM4 gene at 6p21.3 (encoding glutamate receptor metabotropic 4; rs1906953; P = 8.1 x 10(-9)) and a locus in the gene desert at 2p25.2 (rs7591996 and rs10208273; P = 1.0 x 10(-8) and 2.9 x 10(-7), respectively). These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma. en
dc.description.sponsorship Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health
dc.description.sponsorship Bone Cancer Research Trust UK
dc.description.sponsorship National Cancer Institute, US National Institutes of Health
dc.description.sponsorship WWWW (QuadW) Foundation to the Children's Oncology Group
dc.description.sponsorship Ontario Research Fund
dc.description.sponsorship Canadian Foundation for Innovation
dc.description.sponsorship Regione Emilia-Romagna
dc.description.sponsorship Royal National Orthopaedic Hospital Musculoskeletal Research Programme
dc.description.sponsorship Biobank
dc.description.sponsorship National Institute for Health Research UCL Hospitals (UCLH) Biomedical Research Centre
dc.description.sponsorship UCL Experimental Cancer Centre
dc.description.sponsorship Fondo de Investigacion Sanitaria (FIS)
dc.description.sponsorship Instituto de Salud Carlos III (ISCIII)
dc.description.sponsorship Caja de Ahorros de Navarra (CAN) Programme 'Tu eliges, tu decides'
dc.description.sponsorship Asociacion Espanola Contra el Cancer (AECC) project
dc.format.extent 799-+
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.relation.ispartof Nature Genetics
dc.rights Acesso restrito
dc.title Genome-wide association study identifies two susceptibility loci for osteosarcoma en
dc.type Artigo
dc.contributor.institution NCI
dc.contributor.institution Nationwide Childrens Hosp
dc.contributor.institution Ohio State Univ
dc.contributor.institution Childrens Hosp Montefiore
dc.contributor.institution UCL
dc.contributor.institution Royal Natl Orthopaed Hosp NHS Trust
dc.contributor.institution Univ Toronto
dc.contributor.institution Univ Navarra
dc.contributor.institution AY Ankara Oncol Training & Res Hosp
dc.contributor.institution Orthopaed Rizzoli Inst
dc.contributor.institution Univ Minnesota
dc.contributor.institution Univ So Calif
dc.contributor.institution Stanford Univ
dc.contributor.institution Lucile Packard Childrens Hosp
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Melbourne
dc.contributor.institution Harvard Univ
dc.contributor.institution Ctr Nacl Invest Oncol
dc.contributor.institution Ctr Res Environm Epidemiol CREAL
dc.contributor.institution IMIM Hosp Mar Med Res Inst
dc.contributor.institution Network Biomed Res Ctr Epidemiol & Publ Hlth CIBE
dc.contributor.institution Natl Sch Publ Hlth
dc.description.affiliation NCI, Div Canc Epidemiol & Genet, US NIH, Bethesda, MD 20892 USA
dc.description.affiliation NCI, Canc Genom Res Lab, Div Canc Epidemiol & Genet, SAIC Frederick Inc,NCI Frederick, Frederick, MD 21701 USA
dc.description.affiliation Nationwide Childrens Hosp, Columbus, OH USA
dc.description.affiliation Ohio State Univ, Dept Pathol & Pediat, Columbus, OH 43210 USA
dc.description.affiliation Childrens Hosp Montefiore, Albert Einstein Coll Med, Bronx, NY USA
dc.description.affiliation NCI, Ctr Canc Res, US NIH, Bethesda, MD 20892 USA
dc.description.affiliation UCL, Inst Canc, London, England
dc.description.affiliation Royal Natl Orthopaed Hosp NHS Trust, Stanmore, Middx, England
dc.description.affiliation Univ Toronto, Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Litwin Ctr Canc Genet, Toronto, ON M5G 1X5, Canada
dc.description.affiliation Univ Navarra, Univ Navarra Clin, Dept Pediat, E-31080 Pamplona, Spain
dc.description.affiliation AY Ankara Oncol Training & Res Hosp, Dept Pediat Oncol, Ankara, Turkey
dc.description.affiliation Orthopaed Rizzoli Inst, Expt Oncol Lab, Bologna, Italy
dc.description.affiliation Univ Minnesota, Dept Pediat, Div Epidemiol & Clin Res, Minneapolis, MN 55455 USA
dc.description.affiliation Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA
dc.description.affiliation Stanford Univ, Palo Alto, CA 94304 USA
dc.description.affiliation Lucile Packard Childrens Hosp, Dept Pediat Hematol Oncol, Palo Alto, CA USA
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Grp Apoio Adolescente & Crianca Com Canc GRAACC, Pediat Oncol Inst, São Paulo, Brazil
dc.description.affiliation Univ Melbourne, Sir Peter MacCallum Dept Oncol, East Melbourne, Vic, Australia
dc.description.affiliation Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA
dc.description.affiliation Ctr Nacl Invest Oncol, Madrid, Spain
dc.description.affiliation Ctr Res Environm Epidemiol CREAL, Barcelona, Spain
dc.description.affiliation IMIM Hosp Mar Med Res Inst, Barcelona, Spain
dc.description.affiliation Network Biomed Res Ctr Epidemiol & Publ Hlth CIBE, Barcelona, Spain
dc.description.affiliation Natl Sch Publ Hlth, Athens, Greece
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Grp Apoio Adolescente & Crianca Com Canc GRAACC, Pediat Oncol Inst, São Paulo, Brazil
dc.description.sponsorshipID National Cancer Institute, US National Institutes of Health: U10 CA98543
dc.description.sponsorshipID National Cancer Institute, US National Institutes of Health: U24 CA114766
dc.description.sponsorshipID : PI10/01580
dc.identifier.doi 10.1038/ng.2645
dc.description.source Web of Science
dc.identifier.wos WOS:000321005200015



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