Androgen deprivation from pre-puberty to peripuberty interferes in proteins expression in pubertal and adult rat epididymis

Androgen deprivation from pre-puberty to peripuberty interferes in proteins expression in pubertal and adult rat epididymis

Author Perobelli, Juliana Elaine Google Scholar
Patrao, Marilia Tavares Coutinho da Costa Autor UNIFESP Google Scholar
Fernandez, Carla D. B. Google Scholar
Sanabria, Marciana Google Scholar
Klinefelter, Gary R. Google Scholar
Avellar, Maria Christina W. Google Scholar
Kempinas, Wilma D. G. Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
UNESP Univ Estadual Paulista
United States Environm Protect Agcy
Abstract Few studies have focused on experimental testosterone deprivation in immature animals. Therefore, this study used sexually immature rats aiming to evaluate the testes and epididymis histology and proteins expression in these organs on PND50 and 75, after premature antiandrogen exposure, from PND21 to 44. Although the androgen deprivation from pre-puberty up to peripuberty did not alter the histological organization of the testes and epididymis either at puberty or at adulthood, the treatment impaired the expression of specific proteins in epididymal tissue at puberty and adulthood (androgen receptor, calmodulin, Rab11A). These changes may be related to impaired epididymal function, sperm quality and fertility capacity as observed in a previous study. Further studies are necessary to better investigate the molecular mechanisms involved in the impairment on reproductive competence of male rats after precocious hormonal injury. (c) 2013 Elsevier Inc. All rights reserved.
Keywords Antiandrogen
Rat
Epididymis
Peripuberty
Protein expression
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: FAPESP 07/59079-4
CNPq: 501339/2010-8
CNPq: 304958/2009-3
Date 2013-07-01
Published in Reproductive Toxicology. Oxford: Pergamon-Elsevier B.V., v. 38, p. 65-71, 2013.
ISSN 0890-6238 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 65-71
Origin http://dx.doi.org/10.1016/j.reprotox.2013.03.004
Access rights Closed access
Type Article
Web of Science ID WOS:000319535200007
URI http://repositorio.unifesp.br/handle/11600/36500

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